Clinical and immunologic features of recurrent herpes zoster (HZ).

• 資料種別: 博士論文
• タイトル: Clinical and immunologic features of recurrent herpes zoster (HZ).
• 著者・編者: Nakamura, Yuki; Miyagawa, Fumi; Okazaki, Aiko; Okuno, Yoshinobu; Mori, Yasuko; Iso, Hiroyasu; Yamanishi, Koichi; Asada, Hideo; Shozu Herpes Zoster Study Group
• 著者標目: Nakamura, Yuki; Miyagawa, Fumi; Okazaki, Aiko; Okuno, Yoshinobu; Mori, Yasuko; Iso, Hiroyasu; Yamanishi, Koichi; Asada, Hideo; Shozu Herpes Zoster Study Group
• 出版事項: Elsevier
• 出版年月日等: 2016-11
• 出版年（W3CDTF）: 2016-11
• 並列タイトル等: 再発性帯状疱疹の臨床的、免疫学的特徴
• タイトル（掲載誌）: Journal of the American Academy of Dermatology
• 巻号年月日等（掲載誌）: 75 5
• 掲載巻: 75
• 掲載号: 5
• 掲載ページ: 950-956
• ISSN（掲載誌）: ISSN : 0190-9622
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2017-09-27
• 報告番号: 甲第674号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: cell-mediated immunity; humoral immunity; large-scale community-based prospective cohort study; primary herpes zoster; recurrent herpes zoster; varicella-zoster virus
• 対象利用者: 一般
• 一般注記: type:Thesis; BACKGROUND: Recurrent herpes zoster (HZ) is thought to be rare, but there have been few large-scale studies of recurrent HZ. OBJECTIVE: We conducted a large-scale prospective cohort study to characterize recurrent HZ. METHODS: We examined 12,522 participants aged 50 years or older in Shozu County and followed them up for 3 years. We compared the incidence of HZ and postherpetic neuralgia, severity of skin lesions and acute pain, cell-mediated immunity, and varicella-zoster virus-specific antibody titer between primary and recurrent HZ. RESULTS: A total of 401 participants developed HZ: 341 with primary HZ and 60 with recurrent HZ. Skin lesions and acute pain were significantly milder and the incidence of postherpetic neuralgia was lower in patients aged 50 to 79 years with recurrent HZ than in those with primary HZ. Varicella-zoster virus skin test induced a stronger reaction in patients aged 50 to 79 years with recurrent HZ than in those with primary HZ. LIMITATIONS: Information on previous HZ episodes was self-reported by participants, so it could not be confirmed that they actually had a history of HZ. CONCLUSION: Recurrent HZ was associated with milder clinical symptoms than primary HZ, probably because of stronger varicella-zoster virus-specific cell-mediated immunity in the patients with recurrence.; 博士（医学）・甲第674号・平成29年9月27日; Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.; identifier:Journal of the American Academy of Dermatology Vol.75 No.5 p.950-956.e1 (2016 Nov); identifier:01909622; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3380; identifier:Journal of the American Academy of Dermatology, 75(5): 950-956
• 一次資料へのリンクURL: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3380/1/01%e7%94%b2674%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3380/2/02%e7%94%b2674%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3380/3/03%e7%94%b2674%e6%9c%ac%e6%96%87.pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1016/j.jaad.2016.05.037
• 掲載誌（NCID）: AA00256724; https://ci.nii.ac.jp/ncid/AA00256724
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU