Clinical and immunologic features of recurrent herpes zoster (HZ).

• Material Type: 博士論文
• Title: Clinical and immunologic features of recurrent herpes zoster (HZ).
• Author/Editor: Nakamura, Yuki; Miyagawa, Fumi; Okazaki, Aiko; Okuno, Yoshinobu; Mori, Yasuko; Iso, Hiroyasu; Yamanishi, Koichi; Asada, Hideo; Shozu Herpes Zoster Study Group
• Author Heading: Nakamura, Yuki; Miyagawa, Fumi; Okazaki, Aiko; Okuno, Yoshinobu; Mori, Yasuko; Iso, Hiroyasu; Yamanishi, Koichi; Asada, Hideo; Shozu Herpes Zoster Study Group
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2016-11
• Publication Date (W3CDTF): 2016-11
• Alternative Title: 再発性帯状疱疹の臨床的、免疫学的特徴
• Periodical title: Journal of the American Academy of Dermatology
• No. or year of volume/issue: 75 5
• Volume: 75
• Issue: 5
• Pages: 950-956
• ISSN (Periodical Title): ISSN : 0190-9622
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2017-09-27
• Dissertation Number: 甲第674号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: cell-mediated immunity; humoral immunity; large-scale community-based prospective cohort study; primary herpes zoster; recurrent herpes zoster; varicella-zoster virus
• Target Audience: 一般
• Note (General): type:Thesis; BACKGROUND: Recurrent herpes zoster (HZ) is thought to be rare, but there have been few large-scale studies of recurrent HZ. OBJECTIVE: We conducted a large-scale prospective cohort study to characterize recurrent HZ. METHODS: We examined 12,522 participants aged 50 years or older in Shozu County and followed them up for 3 years. We compared the incidence of HZ and postherpetic neuralgia, severity of skin lesions and acute pain, cell-mediated immunity, and varicella-zoster virus-specific antibody titer between primary and recurrent HZ. RESULTS: A total of 401 participants developed HZ: 341 with primary HZ and 60 with recurrent HZ. Skin lesions and acute pain were significantly milder and the incidence of postherpetic neuralgia was lower in patients aged 50 to 79 years with recurrent HZ than in those with primary HZ. Varicella-zoster virus skin test induced a stronger reaction in patients aged 50 to 79 years with recurrent HZ than in those with primary HZ. LIMITATIONS: Information on previous HZ episodes was self-reported by participants, so it could not be confirmed that they actually had a history of HZ. CONCLUSION: Recurrent HZ was associated with milder clinical symptoms than primary HZ, probably because of stronger varicella-zoster virus-specific cell-mediated immunity in the patients with recurrence.; 博士（医学）・甲第674号・平成29年9月27日; Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.; identifier:Journal of the American Academy of Dermatology Vol.75 No.5 p.950-956.e1 (2016 Nov); identifier:01909622; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3380; identifier:Journal of the American Academy of Dermatology, 75(5): 950-956
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3380/1/01%e7%94%b2674%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3380/2/02%e7%94%b2674%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3380/3/03%e7%94%b2674%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.jaad.2016.05.037
• Periodical Title (NCID): AA00256724; https://ci.nii.ac.jp/ncid/AA00256724
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU