Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells.

• 資料種別: 博士論文
• タイトル: Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells.
• 著者・編者: Mikami, Shinji; Ota, Ichiro; Masui, Takashi; Itaya-Hironaka, Asako; Shobatake, Ryogo; Okamoto, Hideyuki; Takasawa, Shin; Kitahara, Tadashi
• 著者標目: Mikami, Shinji; Ota, Ichiro; Masui, Takashi; Itaya-Hironaka, Asako; Shobatake, Ryogo; Okamoto, Hideyuki; Takasawa, Shin; Kitahara, Tadashi
• 出版事項: Spandidos Publications
• 出版年月日等: 2016-10
• 出版年（W3CDTF）: 2016-10
• 並列タイトル等: 頭頸部癌細胞におけるレスベラトロールのREG III発現誘導効果と癌の進展抑制・治療向上効果
• タイトル（掲載誌）: International journal of oncology
• 巻号年月日等（掲載誌）: 49 4
• 掲載巻: 49
• 掲載号: 4
• 掲載ページ: 1553-1560
• ISSN（掲載誌）: ISSN : 1019-6439
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2018-03-15
• 報告番号: 甲第682号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: polyphenol; regenerating gene family; head and neck; squamous cell carcinoma; chemosensitivity; radiosensitivity
• 対象利用者: 一般
• 一般注記: type:Thesis; Identification of reliable markers of chemo- and radiosensitivity and the key molecules that enhance the susceptibility of head and neck squamous cell carcinoma (HNSCC) to anticancer treatments is highly desirable. Previously, we have reported that regenerating gene (REG) Ⅲ expression was such a marker associated with an improved survival rate for HNSCC patients. In the present study, we investigated the stimulators for induction of REG Ⅲ expression using REG Ⅲ promoter assay in HNSCC cells transfected with REG Ⅲ promoter vector. We tested inflammatory cytokines, growth factors, polyphenols, PPARγ activator of thiazolidinediones, and histone deacetylase inhibitors, and found that 3,4',5-trihydroxy-trans-stilbene (resveratrol) significantly increased the REG Ⅲ promoter activity and the mRNA levels of REG Ⅲ in HNSCC cells. Moreover, we demonstrated the effect of resveratrol on cancer cell progression, such as cell proliferation, chemo‑ and radiosensitivity and cancer invasion of HNSCC cells. Resveratrol significantly inhibited cell growth, enhanced chemo‑ and radiosensitivity, and blocked cancer invasion of HNSCC cells. These data suggested that resveratrol could inhibit cancer progression through the REG Ⅲ expression pathway in HNSCC cells.; 博士（医学）・甲第682号・平成30年3月15日; Copyright © Spandidos Publications 2017. All rights reserved.; The Spandidos Publications link is available at " https://doi.org/10.3892/ijo.2016.3664 "; identifier:International journal of oncology Vol.49 No.4 p.1553-1560 (2016 Oct); identifier:10196439; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3427; identifier:International journal of oncology, 49(4): 1553-1560
• 一次資料へのリンクURL: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3427/1/01%e7%94%b2682%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3427/2/02%e7%94%b2682%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3427/3/03%e7%94%b2682%e6%9c%ac%e6%96%87.pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.3892/ijo.2016.3664
• 掲載誌（NCID）: AA10992511; https://ci.nii.ac.jp/ncid/AA10992511
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU