Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells.

• Material Type: 博士論文
• Title: Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells.
• Author/Editor: Mikami, Shinji; Ota, Ichiro; Masui, Takashi; Itaya-Hironaka, Asako; Shobatake, Ryogo; Okamoto, Hideyuki; Takasawa, Shin; Kitahara, Tadashi
• Author Heading: Mikami, Shinji; Ota, Ichiro; Masui, Takashi; Itaya-Hironaka, Asako; Shobatake, Ryogo; Okamoto, Hideyuki; Takasawa, Shin; Kitahara, Tadashi
• Publication, Distribution, etc.: Spandidos Publications
• Publication Date: 2016-10
• Publication Date (W3CDTF): 2016-10
• Alternative Title: 頭頸部癌細胞におけるレスベラトロールのREG III発現誘導効果と癌の進展抑制・治療向上効果
• Periodical title: International journal of oncology
• No. or year of volume/issue: 49 4
• Volume: 49
• Issue: 4
• Pages: 1553-1560
• ISSN (Periodical Title): ISSN : 1019-6439
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2018-03-15
• Dissertation Number: 甲第682号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: polyphenol; regenerating gene family; head and neck; squamous cell carcinoma; chemosensitivity; radiosensitivity
• Target Audience: 一般
• Note (General): type:Thesis; Identification of reliable markers of chemo- and radiosensitivity and the key molecules that enhance the susceptibility of head and neck squamous cell carcinoma (HNSCC) to anticancer treatments is highly desirable. Previously, we have reported that regenerating gene (REG) Ⅲ expression was such a marker associated with an improved survival rate for HNSCC patients. In the present study, we investigated the stimulators for induction of REG Ⅲ expression using REG Ⅲ promoter assay in HNSCC cells transfected with REG Ⅲ promoter vector. We tested inflammatory cytokines, growth factors, polyphenols, PPARγ activator of thiazolidinediones, and histone deacetylase inhibitors, and found that 3,4',5-trihydroxy-trans-stilbene (resveratrol) significantly increased the REG Ⅲ promoter activity and the mRNA levels of REG Ⅲ in HNSCC cells. Moreover, we demonstrated the effect of resveratrol on cancer cell progression, such as cell proliferation, chemo‑ and radiosensitivity and cancer invasion of HNSCC cells. Resveratrol significantly inhibited cell growth, enhanced chemo‑ and radiosensitivity, and blocked cancer invasion of HNSCC cells. These data suggested that resveratrol could inhibit cancer progression through the REG Ⅲ expression pathway in HNSCC cells.; 博士（医学）・甲第682号・平成30年3月15日; Copyright © Spandidos Publications 2017. All rights reserved.; The Spandidos Publications link is available at " https://doi.org/10.3892/ijo.2016.3664 "; identifier:International journal of oncology Vol.49 No.4 p.1553-1560 (2016 Oct); identifier:10196439; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3427; identifier:International journal of oncology, 49(4): 1553-1560
• Source: comment：fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3427/1/01%e7%94%b2682%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3427/2/02%e7%94%b2682%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3427/3/03%e7%94%b2682%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.3892/ijo.2016.3664
• Periodical Title (NCID): AA10992511; https://ci.nii.ac.jp/ncid/AA10992511
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU