Comparison of redox parameters in ovarian endometrioma and its malignant transformation.

• 資料種別: 博士論文
• タイトル: Comparison of redox parameters in ovarian endometrioma and its malignant transformation.
• 著者・編者: Fujimoto, Yoshikatsu; Imanaka, Shogo; Yamada, Yuki; Ogawa, Kenji; Ito, Fuminori; Kawahara, Naoki; Yoshimoto, Chiharu; Kobayashi, Hiroshi
• 著者標目: Fujimoto, Yoshikatsu; Imanaka, Shogo; Yamada, Yuki; Ogawa, Kenji; Ito, Fuminori; Kawahara, Naoki; Yoshimoto, Chiharu; Kobayashi, Hiroshi
• 出版事項: Spandidos Publications
• 出版年月日等: 2018-10
• 出版年（W3CDTF）: 2018-10
• 並列タイトル等: 卵巣チョコレート嚢胞とその悪性転化における酸化抗酸化パラメーターの比較
• タイトル（掲載誌）: Oncology letters
• 巻号年月日等（掲載誌）: 16 4
• 掲載巻: 16
• 掲載号: 4
• 掲載ページ: 5257-5264
• ISSN（掲載誌）: ISSN : 1792-1074
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2020-09-30
• 報告番号: 乙第1472号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: ovarian endometrioma; endometriosis-associated ovarian cancer; 8-hydroxy-2-deoxyguanosine; heme oxygenase-1; total antioxidant capacity
• 対象利用者: 一般
• 一般注記: type:Thesis; The present study aimed to evaluate the levels of oxidative stress and antioxidant markers in benign endometrioma (OE) and its malignant transformation [endometriosis-associated ovarian cancer (EAOC)] by measuring 8-hydroxy-2-deoxyguanosine (8-OHdG), heme oxygenase-1 (HO-1) and total antioxidant capacity (TAC/Heme-iron) alterations associated with disease progression. Cyst fluid samples from 44 patients with OE and 14 patients with EAOC were studied using an enzyme-linked immunosorbent assay. A χ2 test, t-test and Pearson correlation test were performed using SPSS version 22.0. The cut-off point, sensitivity and specificity of each marker for EAOC diagnosis were evaluated by receiver operating characteristic curve analysis. Cyst fluid 8-OHdG and HO-1 levels in the EAOC group were significantly decreased compared with the OE subjects (P=0.013 and P<0.001, respectively). The levels of TAC/Heme-iron in patients with EAOC were significantly higher compared with those in the OE subjects (P<0.001). The present study demonstrated a positive correlation between 8-OHdG and HO-1 levels (P=0.012). HO-1 exhibited the highest discriminant value for EAOC (Area Under the Curve=0.901). The optimal cut-off point of HO-1 for the diagnosis of EAOC was 2.314 ng/ml, with a sensitivity and specifity of 95.2 and 85.7%, respectively. The present study revealed a clear separation between the overall redox state in OE and EAOC. It was concluded that characteristic alterations in important factors in redox may be helpful for understanding the pathogenesis of the malignant transformation of endometriosis.; 博士（医学）・乙第1472号・令和2年9月30日; Copyright © 2018, Spandidos Publications; Articles from Oncology Letters are provided here courtesy of Spandidos Publications.; The publication is available at Spandidos Publications via https://doi.org/10.3892/ol.2018.9242; identifier:Oncology letters Vol.16 No.4 p.5257-5264 (2018 Oct); identifier:17921074; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3788; identifier:Oncology letters, 16(4): 5257-5264
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.3892/ol.2018.9242
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

目次

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3788/1/01%e4%b9%991472%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3788/2/02%e4%b9%991472%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3788/3/03%e4%b9%991472%e6%9c%ac%e6%96%87.pdf fulltext