Comparison of redox parameters in ovarian endometrioma and its malignant transformation.

• Material Type: 博士論文
• Title: Comparison of redox parameters in ovarian endometrioma and its malignant transformation.
• Author/Editor: Fujimoto, Yoshikatsu; Imanaka, Shogo; Yamada, Yuki; Ogawa, Kenji; Ito, Fuminori; Kawahara, Naoki; Yoshimoto, Chiharu; Kobayashi, Hiroshi
• Author Heading: Fujimoto, Yoshikatsu; Imanaka, Shogo; Yamada, Yuki; Ogawa, Kenji; Ito, Fuminori; Kawahara, Naoki; Yoshimoto, Chiharu; Kobayashi, Hiroshi
• Publication, Distribution, etc.: Spandidos Publications
• Publication Date: 2018-10
• Publication Date (W3CDTF): 2018-10
• Alternative Title: 卵巣チョコレート嚢胞とその悪性転化における酸化抗酸化パラメーターの比較
• Periodical title: Oncology letters
• No. or year of volume/issue: 16 4
• Volume: 16
• Issue: 4
• Pages: 5257-5264
• ISSN (Periodical Title): ISSN : 1792-1074
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2020-09-30
• Dissertation Number: 乙第1472号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: ovarian endometrioma; endometriosis-associated ovarian cancer; 8-hydroxy-2-deoxyguanosine; heme oxygenase-1; total antioxidant capacity
• Target Audience: 一般
• Note (General): type:Thesis; The present study aimed to evaluate the levels of oxidative stress and antioxidant markers in benign endometrioma (OE) and its malignant transformation [endometriosis-associated ovarian cancer (EAOC)] by measuring 8-hydroxy-2-deoxyguanosine (8-OHdG), heme oxygenase-1 (HO-1) and total antioxidant capacity (TAC/Heme-iron) alterations associated with disease progression. Cyst fluid samples from 44 patients with OE and 14 patients with EAOC were studied using an enzyme-linked immunosorbent assay. A χ2 test, t-test and Pearson correlation test were performed using SPSS version 22.0. The cut-off point, sensitivity and specificity of each marker for EAOC diagnosis were evaluated by receiver operating characteristic curve analysis. Cyst fluid 8-OHdG and HO-1 levels in the EAOC group were significantly decreased compared with the OE subjects (P=0.013 and P<0.001, respectively). The levels of TAC/Heme-iron in patients with EAOC were significantly higher compared with those in the OE subjects (P<0.001). The present study demonstrated a positive correlation between 8-OHdG and HO-1 levels (P=0.012). HO-1 exhibited the highest discriminant value for EAOC (Area Under the Curve=0.901). The optimal cut-off point of HO-1 for the diagnosis of EAOC was 2.314 ng/ml, with a sensitivity and specifity of 95.2 and 85.7%, respectively. The present study revealed a clear separation between the overall redox state in OE and EAOC. It was concluded that characteristic alterations in important factors in redox may be helpful for understanding the pathogenesis of the malignant transformation of endometriosis.; 博士（医学）・乙第1472号・令和2年9月30日; Copyright © 2018, Spandidos Publications; Articles from Oncology Letters are provided here courtesy of Spandidos Publications.; The publication is available at Spandidos Publications via https://doi.org/10.3892/ol.2018.9242; identifier:Oncology letters Vol.16 No.4 p.5257-5264 (2018 Oct); identifier:17921074; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3788; identifier:Oncology letters, 16(4): 5257-5264
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.3892/ol.2018.9242
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3788/1/01%e4%b9%991472%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3788/2/02%e4%b9%991472%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3788/3/03%e4%b9%991472%e6%9c%ac%e6%96%87.pdf fulltext