並列タイトル等エストロゲン受容体βは若齢雌マウスの筋成長と再生を制御する
授与機関名Nagasaki University (長崎大学)
一般注記Estrogens are female sex hormones that are important for comprehensively maintaining muscle function, and an insufficiency affects muscle strength and regeneration in females. However, it is still unclear whether estrogen signaling is mediated through receptors. To investigate the specific role of estrogen receptor β (ERβ) in skeletal muscle and satellite cells (muscle stem cells), we generated muscle-specific ERβ-knockout (mKO) and satellite cell-specific ERβ-knockout (scKO) mice, respectively. Young female mKO mice displayed a decrease in fast-type dominant muscle mass. Female, but not male, scKO mice exhibited impaired muscle regeneration following acute muscle injury, probably due to reduced proliferation and increased apoptosis of satellite cells. RNA-sequencing analysis revealed that loss of ERβ in satellite cells altered gene expression of extracellular matrix components, including laminin and collagen. The results indicate that the estrogen-ERβ pathway is a sex-specific regulatory mechanism that controls muscle growth and regeneration in female mice.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1268号 学位授与年月日:令和2年9月2日
Author: Daiki Seko, Ryo Fujita, Yuriko Kitajima, Kodai Nakamura, Yuuki Imai, Yusuke Ono
Citation: Stem Cell Reports, 15(3), pp.577-586; 2020
identifier:Nagasaki University (長崎大学), 博士(医学) (2020-09-02)
一次資料へのリンクURLhttps://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=49&item_no=1&attribute_id=70&file_no=1 (fulltext)
著作権情報c 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
関連情報http://hdl.handle.net/10069/40338
関連情報(DOI)10.1016/j.stemcr.2020.07.017
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース(IRDB)(機関リポジトリ)