Estrogen receptor β controls muscle growth and regeneration in young female mice

Material type: 博士論文

Author: 瀬古, 大暉

Publisher: Cell Press

Publication date: 2020-09-02

Material Format: Digital

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Name of awarding university/degree: Nagasaki University (長崎大学),博士(医学)

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Note (General)：: Estrogens are female sex hormones that are important for comprehensively maintaining muscle function, and an insufficiency affects muscle strength and...

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Material Type: 博士論文
Title: Estrogen receptor β controls muscle growth and regeneration in young female mice
Author/Editor: 瀬古, 大暉
Author Heading: 瀬古, 大暉
Publication, Distribution, etc.: Cell Press
Publication Date: 2020-09-02
Publication Date (W3CDTF): 2020-09-02
Alternative Title: エストロゲン受容体βは若齢雌マウスの筋成長と再生を制御する
Periodical title: Stem Cell Reports
No. or year of volume/issue: 15 3
Volume: 15
Issue: 3
Pages: 577-586
ISSN (Periodical Title): ISSN : 2213-6711
Degree grantor/type: Nagasaki University (長崎大学)
Date Granted: 2020-09-02
Dissertation Number: 甲医歯薬第1268号
Degree Type: 博士(医学)
Text Language Code: eng
Subject Heading: estrogen receptor β
estrogens
muscle mass
muscle growth
muscle regeneration
muscle stem cells
Target Audience: 一般
Note (General): Estrogens are female sex hormones that are important for comprehensively maintaining muscle function, and an insufficiency affects muscle strength and regeneration in females. However, it is still unclear whether estrogen signaling is mediated through receptors. To investigate the specific role of estrogen receptor β (ERβ) in skeletal muscle and satellite cells (muscle stem cells), we generated muscle-specific ERβ-knockout (mKO) and satellite cell-specific ERβ-knockout (scKO) mice, respectively. Young female mKO mice displayed a decrease in fast-type dominant muscle mass. Female, but not male, scKO mice exhibited impaired muscle regeneration following acute muscle injury, probably due to reduced proliferation and increased apoptosis of satellite cells. RNA-sequencing analysis revealed that loss of ERβ in satellite cells altered gene expression of extracellular matrix components, including laminin and collagen. The results indicate that the estrogen-ERβ pathway is a sex-specific regulatory mechanism that controls muscle growth and regeneration in female mice.
長崎大学学位論文学位記番号:博(医歯薬)甲第1268号学位授与年月日:令和2年9月2日
Author: Daiki Seko, Ryo Fujita, Yuriko Kitajima, Kodai Nakamura, Yuuki Imai, Yusuke Ono
Citation: Stem Cell Reports, 15(3), pp.577-586; 2020
identifier:Nagasaki University (長崎大学), 博士(医学) (2020-09-02)
Source: fulltext
https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=49&item_no=1&attribute_id=70&file_no=1
Access Restrictions: インターネット公開
Rights (production): c 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Related Material: http://hdl.handle.net/10069/40338
Related Material (DOI): 10.1016/j.stemcr.2020.07.017
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ