並列タイトル等ネーザルハイフローはプロポフォール鎮静中の換気を改善する健康被験者でのランダム化クロスオーバー研究
タイトル（掲載誌）Respiratory Physiology & Neurobiology
授与機関名Nagasaki University (長崎大学)
一般注記Objective: Hypoventilation and carbon dioxide (CO2) retention are common during sedation. The current study investigated the ventilation responses to nasal high flow (NHF) during sedation with propofol. Methods: NHF of 30?L/min and 60?L/min with room air was applied during wakefulness and sedation in 10 male volunteers. Ventilation was monitored by respiratory inductance plethysmography, transcutaneous partial pressure of CO2 (TcCO2), and SpO2. Results: During sedation, NHF of 30?L/min and 60?L/min reduced the TcCO2 by 2.9?±?2.7?mmHg (p = 0.025) and by 3.6?±?3.4?mmHg (p = 0.024) without affecting SpO2 and reduced the mean respiratory rate by 3?±?3 breaths/min (p = 0.011) and by 4?±?3 breaths/min (p = 0.003), respectively. Conclusion: During sedation with propofol, NHF without supplemental oxygen attenuated CO2 retention and reduced the respiratory rate. The findings show that NHF can improve ventilation during sedation, which may reduce the risk of complications related to hypoventilation.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1256号 学位授与年月日:令和2年6月3日
Author: Gaku Mishima, Takuro Sanuki, James Revie, Max Pinkham, Toshihiro Watanabe, Shinji Kurata, Stanislav Tatkov, Takao Ayuse
Citation: Respiratory Physiology & Neurobiology, 277, 103429; 2020
identifier:Nagasaki University (長崎大学), 博士(歯学) (2020-06-03)
著作権情報c 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
関連情報http://hdl.handle.net/10069/40083
関連情報（DOI）10.1016/j.resp.2020.103429
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）