Nasal high flow improves ventilation during propofol sedation: A randomized cross-over study in healthy volunteers

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Nasal high flow improves ventilation during propofol sedation: A randomized cross-over study in healthy volunteers

Material type: 博士論文

Author: 三島, 岳

Publisher: Elsevier B.V.

Publication date: 2020-06-03

Material Format: Digital

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Name of awarding university/degree: Nagasaki University (長崎大学),博士(歯学)

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Note (General)：: Objective: Hypoventilation and carbon dioxide (CO2) retention are common during sedation. The current study investigated the ventilation responses to ...

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Material Type: 博士論文
Title: Nasal high flow improves ventilation during propofol sedation: A randomized cross-over study in healthy volunteers
Author/Editor: 三島, 岳
Author Heading: 三島, 岳
Publication, Distribution, etc.: Elsevier B.V.
Publication Date: 2020-06-03
Publication Date (W3CDTF): 2020-06-03
Alternative Title: ネーザルハイフローはプロポフォール鎮静中の換気を改善する健康被験者でのランダム化クロスオーバー研究
Periodical title: Respiratory Physiology & Neurobiology
No. or year of volume/issue: 277
Volume: 277
Pages: 103429-
ISSN (Periodical Title): ISSN : 1569-9048
Degree grantor/type: Nagasaki University (長崎大学)
Date Granted: 2020-06-03
Dissertation Number: 甲医歯薬第1256号
Degree Type: 博士(歯学)
Text Language Code: eng
Subject Heading: Sedation
Nasal high flow
Ventilation
Propofol
Carbon dioxide
Target Audience: 一般
Note (General): Objective: Hypoventilation and carbon dioxide (CO2) retention are common during sedation. The current study investigated the ventilation responses to nasal high flow (NHF) during sedation with propofol. Methods: NHF of 30?L/min and 60?L/min with room air was applied during wakefulness and sedation in 10 male volunteers. Ventilation was monitored by respiratory inductance plethysmography, transcutaneous partial pressure of CO2 (TcCO2), and SpO2. Results: During sedation, NHF of 30?L/min and 60?L/min reduced the TcCO2 by 2.9?±?2.7?mmHg (p = 0.025) and by 3.6?±?3.4?mmHg (p = 0.024) without affecting SpO2 and reduced the mean respiratory rate by 3?±?3 breaths/min (p = 0.011) and by 4?±?3 breaths/min (p = 0.003), respectively. Conclusion: During sedation with propofol, NHF without supplemental oxygen attenuated CO2 retention and reduced the respiratory rate. The findings show that NHF can improve ventilation during sedation, which may reduce the risk of complications related to hypoventilation.
長崎大学学位論文学位記番号:博(医歯薬)甲第1256号学位授与年月日:令和2年6月3日
Author: Gaku Mishima, Takuro Sanuki, James Revie, Max Pinkham, Toshihiro Watanabe, Shinji Kurata, Stanislav Tatkov, Takao Ayuse
Citation: Respiratory Physiology & Neurobiology, 277, 103429; 2020
identifier:Nagasaki University (長崎大学), 博士(歯学) (2020-06-03)
Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=846&item_no=1&attribute_id=70&file_no=1 （fulltext）
https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=846&item_no=1&attribute_id=70&file_no=1
Access Restrictions: インターネット公開
Rights (production): c 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
Related Material: http://hdl.handle.net/10069/40083
Related Material (DOI): 10.1016/j.resp.2020.103429
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ