Viral Etiology of Acute Lower Respiratory Tract Infections in Hospitalized Children in Nagasaki, a Regional City of Japan in 2013-2015

• 資料種別: 博士論文
• タイトル: Viral Etiology of Acute Lower Respiratory Tract Infections in Hospitalized Children in Nagasaki, a Regional City of Japan in 2013-2015
• 著者・編者: 蓮把, 朋之
• 著者標目: 蓮把, 朋之
• 出版事項: Wolters Kluwer Health, Inc.
• 出版年月日等: 2020-06-03
• 出版年（W3CDTF）: 2020-06-03
• 並列タイトル等: 2013-2015年日本の地方都市長崎市における急性下気道感染症入院患児の原因ウイルスの解析
• タイトル（掲載誌）: Pediatric Infectious Disease Journal
• 巻号年月日等（掲載誌）: 39 8
• 掲載巻: 39
• 掲載号: 8
• 掲載ページ: 687-693
• ISSN（掲載誌）: ISSN : 0891-3668
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2020-06-03
• 報告番号: 甲医歯薬第1263号
• 学位: 博士(医学)
• 本文の言語コード: eng
• 件名標目: acute lower respiratory tract infections; respiratory pathogens; epidemiology; multiplex polymerase chain reaction; enterovirus D68
• 対象利用者: 一般
• 一般注記: Background: Acute lower respiratory tract infections (ALRIs) are the most common disease for hospitalized children in Japan. The aim of this study was to identify viruses in children hospitalized for ALRIs and to demonstrate epidemiologic and clinical characteristics in Japan. Methods: During a 2-year period from February 2013 to January 2015, we collected nasopharyngeal swab specimens from almost all hospitalized children with ALRIs in Nagasaki, a regional city of Japan, and its environs. Viruses were detected by multiplex polymerase chain reaction from these samples. Results: We detected one or more viruses from 259 (69%) of 374 patients, 227 of whom were infected with a single virus, 30 with 2, and 2 with 3 viruses. Detected viruses in this study were rhinovirus (46.4%), respiratory syncytial virus (29.7%), human metapneumovirus (6.8%), parainfluenza virus (5.5%), enterovirus D68 (3.4%), influenza virus (2.7%), adenovirus (2.4%), bocavirus (2.0%) and Coxsackie virus (1.0%). We detected a seasonal shift in respiratory syncytial virus outbreaks from the 2013?2014 to the 2014?2015 seasons. There was no significant difference in clinical course and severity among those viruses. Patients with a history of asthma or underlying diseases were older and more frequently required oxygen therapy than previously healthy patients. Conclusions: Viral etiology in hospitalized children with ALRIs in Nagasaki, Japan, was similar to that in many other countries. Enterovirus D68, which was recently recognized as a causative agent of severe ALRIs, was also identified in this study area. Severity of ALRIs may depend on underlying disease rather than type of etiologic virus.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1263号 学位授与年月日:令和2年6月3日; Author: Hasuwa, Tomoyuki; Kinoshita, Fumiko; Harada, Sadatomo; Nakashima, Kazuhisa; Yoshihara, Keisuke; Toku, Yuichirou; Moriuchi, Hiroyuki; Yoshida, Lay Myint; Citation: Pediatric Infectious Disease Journal, 39(8), pp.687-693; 2020; identifier:Nagasaki University (長崎大学), 博士(医学) (2020-06-03)
• 一次資料へのリンクURL: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=1022&item_no=1&attribute_id=70&file_no=1 （fulltext）; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=1022&item_no=1&attribute_id=70&file_no=1
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: c 2020 Wolters Kluwer Health, Inc. This is a non-final version of an article published in final form in Pediatric Infectious Disease Journal, 39(8), pp.687-693; 2020.
• 関連情報: http://hdl.handle.net/10069/40090
• 関連情報（DOI）: 10.1097/INF.0000000000002668
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 長崎大学 : 長崎大学学術研究成果リポジトリ