Viral Etiology of Acute Lower Respiratory Tract Infections in Hospitalized Children in Nagasaki, a Regional City of Japan in 2013-2015

• Material Type: 博士論文
• Title: Viral Etiology of Acute Lower Respiratory Tract Infections in Hospitalized Children in Nagasaki, a Regional City of Japan in 2013-2015
• Author/Editor: 蓮把, 朋之
• Author Heading: 蓮把, 朋之
• Publication, Distribution, etc.: Wolters Kluwer Health, Inc.
• Publication Date: 2020-06-03
• Publication Date (W3CDTF): 2020-06-03
• Alternative Title: 2013-2015年日本の地方都市長崎市における急性下気道感染症入院患児の原因ウイルスの解析
• Periodical title: Pediatric Infectious Disease Journal
• No. or year of volume/issue: 39 8
• Volume: 39
• Issue: 8
• Pages: 687-693
• ISSN (Periodical Title): ISSN : 0891-3668
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2020-06-03
• Dissertation Number: 甲医歯薬第1263号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: acute lower respiratory tract infections; respiratory pathogens; epidemiology; multiplex polymerase chain reaction; enterovirus D68
• Target Audience: 一般
• Note (General): Background: Acute lower respiratory tract infections (ALRIs) are the most common disease for hospitalized children in Japan. The aim of this study was to identify viruses in children hospitalized for ALRIs and to demonstrate epidemiologic and clinical characteristics in Japan. Methods: During a 2-year period from February 2013 to January 2015, we collected nasopharyngeal swab specimens from almost all hospitalized children with ALRIs in Nagasaki, a regional city of Japan, and its environs. Viruses were detected by multiplex polymerase chain reaction from these samples. Results: We detected one or more viruses from 259 (69%) of 374 patients, 227 of whom were infected with a single virus, 30 with 2, and 2 with 3 viruses. Detected viruses in this study were rhinovirus (46.4%), respiratory syncytial virus (29.7%), human metapneumovirus (6.8%), parainfluenza virus (5.5%), enterovirus D68 (3.4%), influenza virus (2.7%), adenovirus (2.4%), bocavirus (2.0%) and Coxsackie virus (1.0%). We detected a seasonal shift in respiratory syncytial virus outbreaks from the 2013?2014 to the 2014?2015 seasons. There was no significant difference in clinical course and severity among those viruses. Patients with a history of asthma or underlying diseases were older and more frequently required oxygen therapy than previously healthy patients. Conclusions: Viral etiology in hospitalized children with ALRIs in Nagasaki, Japan, was similar to that in many other countries. Enterovirus D68, which was recently recognized as a causative agent of severe ALRIs, was also identified in this study area. Severity of ALRIs may depend on underlying disease rather than type of etiologic virus.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1263号 学位授与年月日:令和2年6月3日; Author: Hasuwa, Tomoyuki; Kinoshita, Fumiko; Harada, Sadatomo; Nakashima, Kazuhisa; Yoshihara, Keisuke; Toku, Yuichirou; Moriuchi, Hiroyuki; Yoshida, Lay Myint; Citation: Pediatric Infectious Disease Journal, 39(8), pp.687-693; 2020; identifier:Nagasaki University (長崎大学), 博士(医学) (2020-06-03)
• Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=1022&item_no=1&attribute_id=70&file_no=1 （fulltext）; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=1022&item_no=1&attribute_id=70&file_no=1
• Access Restrictions: インターネット公開
• Rights (production): c 2020 Wolters Kluwer Health, Inc. This is a non-final version of an article published in final form in Pediatric Infectious Disease Journal, 39(8), pp.687-693; 2020.
• Related Material: http://hdl.handle.net/10069/40090
• Related Material (DOI): 10.1097/INF.0000000000002668
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ