並列タイトル等ヒト臨床所見に合致した眼底像を呈する有色マウス網膜静脈閉塞症モデルの確立
タイトル（掲載誌）Experimental Eye Research
授与機関名Nagasaki University (長崎大学)
一般注記Retinal vein occlusion (RVO) is a vascular disease that represents characteristic retinal hemorrhage and dilated retinal veins. Despite its clinical importance, its pathogenesis remains largely unknown because of limited opportunities to acquire human retinal samples. Therefore, an animal model that reproduces the clinical features of RVO patients is required for further investigation. In this study, we established a pigmented murine RVO model that reproduced characteristic fundus appearances similar to human RVO findings. Retinal edema in this model was observed in both optical coherence tomography and histological analysis, which is a clinically important outcome. With quantitative real-time PCR analysis on retinal samples, we revealed that the mRNA level of vascular endothelial growth factor (VEGF) increased in the retina induced RVO. Moreover, this retinal edema was reduced by intravitreal injection of anti-VEGF antibody. These results were consistent with human clinical knowledge and suggested that this model could be a useful tool for research into new therapeutic approaches.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1348号 学位授与年月日:令和3年6月2日
Author: Sugao Miyagi, Anri Nishinaka, Takumi Yamamoto, Wataru Otsu, Shinsuke Nakamura, Masamitsu Shimazawa, Takashi Kitaoka, Hideaki Hara
Citation: Experimental Eye Research, 204, 108441; 2021
identifier:Nagasaki University (長崎大学), 博士(医学) (2021-06-02)
一次資料へのリンクURLhttps://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=26668&item_no=1&attribute_id=70&file_no=1 （fulltext）
著作権情報© 2021 Elsevier Ltd. All rights reserved.
関連情報http://hdl.handle.net/10069/00040831
関連情報（DOI）10.1016/j.exer.2021.108441
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）