Establishment of a pigmented murine model abundant with characteristics of retinal vein occlusion

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学術機関リポジトリデータベース（IRDB）（機関リポジトリ）

Establishment of a pigmented murine model abundant with characteristics of retinal vein occlusion

Material type: 博士論文

Author: 宮城, 清弦

Publisher: Elsevier Ltd.

Publication date: 2021-06-02

Material Format: Digital

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Name of awarding university/degree: Nagasaki University (長崎大学),博士(医学)

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Note (General)：: Retinal vein occlusion (RVO) is a vascular disease that represents characteristic retinal hemorrhage and dilated retinal veins. Despite its clinical i...

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Material Type: 博士論文
Title: Establishment of a pigmented murine model abundant with characteristics of retinal vein occlusion
Author/Editor: 宮城, 清弦
Author Heading: 宮城, 清弦
Publication, Distribution, etc.: Elsevier Ltd.
Publication Date: 2021-06-02
Publication Date (W3CDTF): 2021-06-02
Alternative Title: ヒト臨床所見に合致した眼底像を呈する有色マウス網膜静脈閉塞症モデルの確立
Periodical title: Experimental Eye Research
No. or year of volume/issue: 204
Volume: 204
Pages: 108441-
ISSN (Periodical Title): ISSN : 0014-4835
Degree grantor/type: Nagasaki University (長崎大学)
Date Granted: 2021-06-02
Dissertation Number: 甲医歯薬第1348号
Degree Type: 博士(医学)
Text Language Code: eng
Subject Heading: Murine model
Retina
Retinal vein occlusion
VEGF
Target Audience: 一般
Note (General): Retinal vein occlusion (RVO) is a vascular disease that represents characteristic retinal hemorrhage and dilated retinal veins. Despite its clinical importance, its pathogenesis remains largely unknown because of limited opportunities to acquire human retinal samples. Therefore, an animal model that reproduces the clinical features of RVO patients is required for further investigation. In this study, we established a pigmented murine RVO model that reproduced characteristic fundus appearances similar to human RVO findings. Retinal edema in this model was observed in both optical coherence tomography and histological analysis, which is a clinically important outcome. With quantitative real-time PCR analysis on retinal samples, we revealed that the mRNA level of vascular endothelial growth factor (VEGF) increased in the retina induced RVO. Moreover, this retinal edema was reduced by intravitreal injection of anti-VEGF antibody. These results were consistent with human clinical knowledge and suggested that this model could be a useful tool for research into new therapeutic approaches.
長崎大学学位論文学位記番号:博(医歯薬)甲第1348号学位授与年月日:令和3年6月2日
Author: Sugao Miyagi, Anri Nishinaka, Takumi Yamamoto, Wataru Otsu, Shinsuke Nakamura, Masamitsu Shimazawa, Takashi Kitaoka, Hideaki Hara
Citation: Experimental Eye Research, 204, 108441; 2021
identifier:Nagasaki University (長崎大学), 博士(医学) (2021-06-02)
Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=26668&item_no=1&attribute_id=70&file_no=1 （fulltext）
https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=26668&item_no=1&attribute_id=70&file_no=1
Access Restrictions: インターネット公開
Related Material: http://hdl.handle.net/10069/00040831
Related Material (DOI): 10.1016/j.exer.2021.108441
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ