Analysis of HLA class II genes associated with susceptibility to type 1 diabetes in Japanese patients with autoimmune thyroid disease

• 資料種別: 博士論文
• タイトル: Analysis of HLA class II genes associated with susceptibility to type 1 diabetes in Japanese patients with autoimmune thyroid disease
• 著者・編者: 鶴丸, 雅子
• 著者標目: 鶴丸, 雅子
• 出版事項: Nagasaki University School of Medicine
• 出版年月日等: 2021-09-01
• 出版年（W3CDTF）: 2021-09-01
• 並列タイトル等: 日本人自己免疫性甲状腺疾患患者における１型糖尿病疾患感受性に関連するHLA class II遺伝子の解析
• タイトル（掲載誌）: Acta Medica Nagasakiensia
• 巻号年月日等（掲載誌）: 65 2
• 掲載巻: 65
• 掲載号: 2
• 掲載ページ: 37-43
• ISSN（掲載誌）: ISSN : 0001-6055
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2021-09-01
• 報告番号: 甲医歯薬第1367号
• 学位: 博士(医学)
• 本文の言語コード: eng
• 件名標目: HLA class Ⅱ; type1 diabetes (T1D); autoimmune thyroid disease (AITD)
• 対象利用者: 一般
• 一般注記: Objective: Type 1 diabetes (T1D) is an organ-specific autoimmune disease triggered by both genetic and environmental factors. Adult-onset T1D in Japan is frequently associated with autoimmune thyroid disease (AITD), and more than half of the T1D cases are preceded by AITD. We investigated whether the human leukocyte antigen (HLA) class II (DR/DQ) gene, the major genetic risk factor for T1D, is useful in identifying individuals at high risk of developing T1D among Japanese AITD patients.Design/Patients: We genotyped the HLA class II (DR/DQ) gene in 82 patients with AITD complicated with T1D (AITD+T1D), 131 AITD patients without T1D (AITDw/oT1D), and 222 healthy subjects as controls.Results: Compared to the controls, the AITD+T1D group had a significantly higher rate of the T1D-susceptible haplotype DRB1*0405-DQB1*0401, but the AITDw/oT1D group did not. Compared to the controls, the T1D-protective haplotypes DRB1*1501-DQB1*0602/DRB1*1502-DQB1*0601 were significantly less frequent in the AITD+T1D patients but not in the AITDw/oT1D patients. In genotypes combining the DRB1-DQB1 haplotypes susceptible to T1D, only DR4/DR8 was significantly more frequent compared to the controls. We classified the haplotypes into three types (susceptible [S], protective [P] and neutral [N]) to examine their association with T1D development. Compared to the controls, the genotypes S/S and N/P were observed more and less frequently, respectively, in AITD+T1D. No difference in the frequency of those genotypes between AITDw/oT1D and controls was observed.Conclusions: The risk of the future development of T1D in Japanese patients with AITD could be stratified by an analysis of combinations of HLA DRB1-DQB1 haplotypes.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1367号 学位授与年月日:令和3年9月1日; Author: Tsurumaru Masako, Horie Ichiro, Ikeoka Toshiyuki, Abiru Norio, Kawakami Atsushi; Citation: Acta Medica Nagasakiensia , 65(2), pp.37−43; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2021-09-01)
• 一次資料へのリンクURL: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27339&item_no=1&attribute_id=70&file_no=1 （fulltext）; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27339&item_no=1&attribute_id=70&file_no=1
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: (C) 2022 Nagasaki University School of Medicine
• 関連情報: http://hdl.handle.net/10069/00000040954
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 長崎大学 : 長崎大学学術研究成果リポジトリ