Analysis of HLA class II genes associated with susceptibility to type 1 diabetes in Japanese patients with autoimmune thyroid disease

• Material Type: 博士論文
• Title: Analysis of HLA class II genes associated with susceptibility to type 1 diabetes in Japanese patients with autoimmune thyroid disease
• Author/Editor: 鶴丸, 雅子
• Author Heading: 鶴丸, 雅子
• Publication, Distribution, etc.: Nagasaki University School of Medicine
• Publication Date: 2021-09-01
• Publication Date (W3CDTF): 2021-09-01
• Alternative Title: 日本人自己免疫性甲状腺疾患患者における１型糖尿病疾患感受性に関連するHLA class II遺伝子の解析
• Periodical title: Acta Medica Nagasakiensia
• No. or year of volume/issue: 65 2
• Volume: 65
• Issue: 2
• Pages: 37-43
• ISSN (Periodical Title): ISSN : 0001-6055
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2021-09-01
• Dissertation Number: 甲医歯薬第1367号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: HLA class Ⅱ; type1 diabetes (T1D); autoimmune thyroid disease (AITD)
• Target Audience: 一般
• Note (General): Objective: Type 1 diabetes (T1D) is an organ-specific autoimmune disease triggered by both genetic and environmental factors. Adult-onset T1D in Japan is frequently associated with autoimmune thyroid disease (AITD), and more than half of the T1D cases are preceded by AITD. We investigated whether the human leukocyte antigen (HLA) class II (DR/DQ) gene, the major genetic risk factor for T1D, is useful in identifying individuals at high risk of developing T1D among Japanese AITD patients.Design/Patients: We genotyped the HLA class II (DR/DQ) gene in 82 patients with AITD complicated with T1D (AITD+T1D), 131 AITD patients without T1D (AITDw/oT1D), and 222 healthy subjects as controls.Results: Compared to the controls, the AITD+T1D group had a significantly higher rate of the T1D-susceptible haplotype DRB1*0405-DQB1*0401, but the AITDw/oT1D group did not. Compared to the controls, the T1D-protective haplotypes DRB1*1501-DQB1*0602/DRB1*1502-DQB1*0601 were significantly less frequent in the AITD+T1D patients but not in the AITDw/oT1D patients. In genotypes combining the DRB1-DQB1 haplotypes susceptible to T1D, only DR4/DR8 was significantly more frequent compared to the controls. We classified the haplotypes into three types (susceptible [S], protective [P] and neutral [N]) to examine their association with T1D development. Compared to the controls, the genotypes S/S and N/P were observed more and less frequently, respectively, in AITD+T1D. No difference in the frequency of those genotypes between AITDw/oT1D and controls was observed.Conclusions: The risk of the future development of T1D in Japanese patients with AITD could be stratified by an analysis of combinations of HLA DRB1-DQB1 haplotypes.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1367号 学位授与年月日:令和3年9月1日; Author: Tsurumaru Masako, Horie Ichiro, Ikeoka Toshiyuki, Abiru Norio, Kawakami Atsushi; Citation: Acta Medica Nagasakiensia , 65(2), pp.37−43; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2021-09-01)
• Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27339&item_no=1&attribute_id=70&file_no=1 （fulltext）; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27339&item_no=1&attribute_id=70&file_no=1
• Access Restrictions: インターネット公開
• Rights (production): (C) 2022 Nagasaki University School of Medicine
• Related Material: http://hdl.handle.net/10069/00000040954
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ