Influence of chronic sputum symptoms on quality of life in patients with nontuberculous mycobacterial pulmonary disease: a cross-sectional study

• 資料種別: 博士論文
• タイトル: Influence of chronic sputum symptoms on quality of life in patients with nontuberculous mycobacterial pulmonary disease: a cross-sectional study
• 著者・編者: 山根, 主信
• 著者標目: 山根, 主信
• 出版事項: Elsevier B.V.
• 出版年月日等: 2022-03-31
• 出版年（W3CDTF）: 2022-03-31
• 並列タイトル等: 肺非結核性抗酸菌症患者のQOLへ慢性痰症状が与える影響：横断研究
• タイトル（掲載誌）: Respiratory Investigation
• 巻号年月日等（掲載誌）: 60 2
• 掲載巻: 60
• 掲載号: 2
• 掲載ページ: 277-283
• ISSN（掲載誌）: ISSN : 2212-5345
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2022-03-31
• 報告番号: 甲医歯薬第1399号
• 学位: 博士(医学)
• 本文の言語コード: eng
• 件名標目: Sputum; Nontuberculous mycobacteria; HRQOL; Mental health
• 対象利用者: 一般
• 一般注記: Background: The effect of chronic sputum (CS) symptoms on health-related quality of life (HRQOL) in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) has not been studied. The aim of this study was to clarify the differences in the clinical characteristics of NTM-PD patients with and without CS and to investigate the effect of CS on HRQOL.Methods: This cross-sectional study included patients with NTM-PD who were prescribed pulmonary rehabilitation at the Fukujuji Hospital from March 2016 to June 2019. HRQOL was evaluated using the MOS 36-Item Short-Form Health Survey (SF-36).Results: Of the 99 subjects studied, 71 had CS (CS+) (71.7%), and 28 (28.3%) did not have CS (CS-). Patients in the CS + group had a lower body mass index, forced vital capacity percent predicted, and forced expiratory volume in 1 s percent predicted. Regarding the radiological evaluation, the proportion of patients with the fibrocavitary form and the radiological score were significantly higher in the CS + group. The mental component summary (MCS) score of the SF-36 were significantly lower in the CS + group. Multiple regression analysis showed that the presence of CS was independently associated with a lower MCS score of the SF-36.Conclusions: NTM-PD patients with CS had more severe disease, with reduced pulmonary function and severe radiological findings. CS was shown to independently affect HRQOL, especially mental status.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1399号 学位授与年月日:令和4年3月31日; Author: Kazumasa Yamane, Koji Furuuchi, Mitsuru Tabusadani, Satoshi Takao, Yuki Kuroyama, Yusuke Matsumura, Kosuke Mori, Kazuki Ono, Kazuma Kawahara, Shunya Omatsu, Yuki Toyoda, Keiji Fujiwara, Kozo Morimoto, Hideaki Senjyu; Citation: Respiratory Investigation, 60(2), pp. 277-283; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-03-31)
• 一次資料へのリンクURL: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27437&item_no=1&attribute_id=70&file_no=1 （fulltext）; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27437&item_no=1&attribute_id=70&file_no=1
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2021 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.
• 関連情報: http://hdl.handle.net/10069/00041
• 関連情報（DOI）: 10.1016/j.resinv.2021.09.011
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 長崎大学 : 長崎大学学術研究成果リポジトリ