Influence of chronic sputum symptoms on quality of life in patients with nontuberculous mycobacterial pulmonary disease: a cross-sectional study

• Material Type: 博士論文
• Title: Influence of chronic sputum symptoms on quality of life in patients with nontuberculous mycobacterial pulmonary disease: a cross-sectional study
• Author/Editor: 山根, 主信
• Author Heading: 山根, 主信
• Publication, Distribution, etc.: Elsevier B.V.
• Publication Date: 2022-03-31
• Publication Date (W3CDTF): 2022-03-31
• Alternative Title: 肺非結核性抗酸菌症患者のQOLへ慢性痰症状が与える影響：横断研究
• Periodical title: Respiratory Investigation
• No. or year of volume/issue: 60 2
• Volume: 60
• Issue: 2
• Pages: 277-283
• ISSN (Periodical Title): ISSN : 2212-5345
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2022-03-31
• Dissertation Number: 甲医歯薬第1399号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: Sputum; Nontuberculous mycobacteria; HRQOL; Mental health
• Target Audience: 一般
• Note (General): Background: The effect of chronic sputum (CS) symptoms on health-related quality of life (HRQOL) in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) has not been studied. The aim of this study was to clarify the differences in the clinical characteristics of NTM-PD patients with and without CS and to investigate the effect of CS on HRQOL.Methods: This cross-sectional study included patients with NTM-PD who were prescribed pulmonary rehabilitation at the Fukujuji Hospital from March 2016 to June 2019. HRQOL was evaluated using the MOS 36-Item Short-Form Health Survey (SF-36).Results: Of the 99 subjects studied, 71 had CS (CS+) (71.7%), and 28 (28.3%) did not have CS (CS-). Patients in the CS + group had a lower body mass index, forced vital capacity percent predicted, and forced expiratory volume in 1 s percent predicted. Regarding the radiological evaluation, the proportion of patients with the fibrocavitary form and the radiological score were significantly higher in the CS + group. The mental component summary (MCS) score of the SF-36 were significantly lower in the CS + group. Multiple regression analysis showed that the presence of CS was independently associated with a lower MCS score of the SF-36.Conclusions: NTM-PD patients with CS had more severe disease, with reduced pulmonary function and severe radiological findings. CS was shown to independently affect HRQOL, especially mental status.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1399号 学位授与年月日:令和4年3月31日; Author: Kazumasa Yamane, Koji Furuuchi, Mitsuru Tabusadani, Satoshi Takao, Yuki Kuroyama, Yusuke Matsumura, Kosuke Mori, Kazuki Ono, Kazuma Kawahara, Shunya Omatsu, Yuki Toyoda, Keiji Fujiwara, Kozo Morimoto, Hideaki Senjyu; Citation: Respiratory Investigation, 60(2), pp. 277-283; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-03-31)
• Source: fulltext; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27437&item_no=1&attribute_id=70&file_no=1
• Access Restrictions: インターネット公開
• Rights (production): © 2021 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.
• Related Material: http://hdl.handle.net/10069/00041
• Related Material (DOI): 10.1016/j.resinv.2021.09.011
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ