Predictive factor of recurrence after endoscopic papillectomy for ampullary neoplasms

• 資料種別: 博士論文
• タイトル: Predictive factor of recurrence after endoscopic papillectomy for ampullary neoplasms
• 著者・編者: 髙橋, 孝輔
• 著者標目: 髙橋, 孝輔
• 出版事項: John Wiley and Sons Inc
• 出版年月日等: 2022-06-01
• 出版年（W3CDTF）: 2022-06-01
• 並列タイトル等: 十二指腸乳頭部腫瘍に対する内視鏡的乳頭部切除術後の再発予測因子
• タイトル（掲載誌）: Journal of Hepato-Biliary-Pancreatic Sciences
• 巻号年月日等（掲載誌）: 28 7
• 掲載巻: 28
• 掲載号: 7
• 掲載ページ: 625-634
• ISSN（掲載誌）: ISSN : 1868-6974
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2022-06-01
• 報告番号: 甲医歯薬第1457号
• 学位: 博士(医学)
• 本文の言語コード: eng
• 件名標目: adenocarcinoma; ampullary; ampullary adenoma; endoscopic papillectomy; recurrence
• 対象利用者: 一般
• 一般注記: Background/Purpose: Recurrence of ampullary neoplasms after endoscopic papil-lectomy (EP) has not been well elucidated. This study aimed to clarify the predictive factors for recurrences after EP. We also aimed to investigate the retreatment of the recurrent lesions and their outcomes.Methods: This multicenter, retrospective cohort study included 96 patients with am-pullary neoplasms who underwent EP at four tertiary centers between January 2000 and October 2018.Results: The pathological diagnoses of resected specimens confirmed adenoma in 62 and adenocarcinoma in 34 patients (six Tis, 24 T1a, three T1b, one inconclu-sive). Complete resection was confirmed for 79 patients (82.3%). Recurrent lesions were observed in 13 patients (13.5%) during a median follow- up of 3 months (1- 36 months) after EP. The predictive factors of recurrence were piecemeal resection, and non- negative horizontal or vertical margin in univariate analysis. Non- negative vertical margin was the only independent predictive factor of recurrence in the mul-tivariate analysis. The recurrent lesions were treated endoscopically in 11 patients. Recurrence after the endoscopic retreatments was observed in one patient.Conclusions: Complete resection with negative vertical margin is an important fac-tor in preventing the recurrence of ampullary neoplasms after EP. Endoscopic re-treatments are also feasible for recurrent lesions.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1457号 学位授与年月日:令和4年6月1日; Author: Takahashi Kosuke, Ozawa Eisuke, Yasuda Ichiro, Komatsu Naohiro, Miyaaki Hisamitsu, Ohnita Ken, Yamao Takuji, Oba Kazuo, Ichikawa Tatsuki, Nakao Kazuhiko; Citation: Journal of Hepato-Biliary-Pancreatic Sciences, 28(7), pp.625-634; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-06-01)
• 一次資料へのリンクURL: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27485&item_no=1&attribute_id=70&file_no=1 （fulltext）; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27485&item_no=1&attribute_id=70&file_no=1
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2021 Japanese Society of Hepato-Biliary-Pancreatic Surgery
• 関連情報: http://hdl.handle.net/10069/00041587
• 関連情報（DOI）: 10.1002/jhbp.992
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 長崎大学 : 長崎大学学術研究成果リポジトリ