Predictive factor of recurrence after endoscopic papillectomy for ampullary neoplasms

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学術機関リポジトリデータベース（IRDB）（機関リポジトリ）

Predictive factor of recurrence after endoscopic papillectomy for ampullary neoplasms

Material type: 博士論文

Author: 髙橋, 孝輔

Publisher: John Wiley and Sons Inc

Publication date: 2022-06-01

Material Format: Digital

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Name of awarding university/degree: Nagasaki University (長崎大学),博士(医学)

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Note (General)：: Background/Purpose: Recurrence of ampullary neoplasms after endoscopic papil-lectomy (EP) has not been well elucidated. This study aimed to clarify th...

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Material Type: 博士論文
Title: Predictive factor of recurrence after endoscopic papillectomy for ampullary neoplasms
Author/Editor: 髙橋, 孝輔
Author Heading: 髙橋, 孝輔
Publication, Distribution, etc.: John Wiley and Sons Inc
Publication Date: 2022-06-01
Publication Date (W3CDTF): 2022-06-01
Alternative Title: 十二指腸乳頭部腫瘍に対する内視鏡的乳頭部切除術後の再発予測因子
Periodical title: Journal of Hepato-Biliary-Pancreatic Sciences
No. or year of volume/issue: 28 7
Volume: 28
Issue: 7
Pages: 625-634
ISSN (Periodical Title): ISSN : 1868-6974
Degree grantor/type: Nagasaki University (長崎大学)
Date Granted: 2022-06-01
Dissertation Number: 甲医歯薬第1457号
Degree Type: 博士(医学)
Text Language Code: eng
Subject Heading: adenocarcinoma
ampullary
ampullary adenoma
endoscopic papillectomy
recurrence
Target Audience: 一般
Note (General): Background/Purpose: Recurrence of ampullary neoplasms after endoscopic papil-lectomy (EP) has not been well elucidated. This study aimed to clarify the predictive factors for recurrences after EP. We also aimed to investigate the retreatment of the recurrent lesions and their outcomes.Methods: This multicenter, retrospective cohort study included 96 patients with am-pullary neoplasms who underwent EP at four tertiary centers between January 2000 and October 2018.Results: The pathological diagnoses of resected specimens confirmed adenoma in 62 and adenocarcinoma in 34 patients (six Tis, 24 T1a, three T1b, one inconclu-sive). Complete resection was confirmed for 79 patients (82.3%). Recurrent lesions were observed in 13 patients (13.5%) during a median follow- up of 3 months (1- 36 months) after EP. The predictive factors of recurrence were piecemeal resection, and non- negative horizontal or vertical margin in univariate analysis. Non- negative vertical margin was the only independent predictive factor of recurrence in the mul-tivariate analysis. The recurrent lesions were treated endoscopically in 11 patients. Recurrence after the endoscopic retreatments was observed in one patient.Conclusions: Complete resection with negative vertical margin is an important fac-tor in preventing the recurrence of ampullary neoplasms after EP. Endoscopic re-treatments are also feasible for recurrent lesions.
長崎大学学位論文学位記番号:博(医歯薬)甲第1457号学位授与年月日:令和4年6月1日
Author: Takahashi Kosuke, Ozawa Eisuke, Yasuda Ichiro, Komatsu Naohiro, Miyaaki Hisamitsu, Ohnita Ken, Yamao Takuji, Oba Kazuo, Ichikawa Tatsuki, Nakao Kazuhiko
Citation: Journal of Hepato-Biliary-Pancreatic Sciences, 28(7), pp.625-634; 2022
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-06-01)
Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27485&item_no=1&attribute_id=70&file_no=1 （fulltext）
https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27485&item_no=1&attribute_id=70&file_no=1
Access Restrictions: インターネット公開
Related Material: http://hdl.handle.net/10069/00041587
Related Material (DOI): 10.1002/jhbp.992
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
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Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ