Ineffectiveness of Antiresorptive Agent Drug Holidays in Osteoporosis Patients for Treatment of Medication-Related Osteonecrosis of the Jaw: Consideration from Immunohistological Observation of Osteoclast Suppression and Treatment Outcomes

• 資料種別: 博士論文
• タイトル: Ineffectiveness of Antiresorptive Agent Drug Holidays in Osteoporosis Patients for Treatment of Medication-Related Osteonecrosis of the Jaw: Consideration from Immunohistological Observation of Osteoclast Suppression and Treatment Outcomes
• 著者・編者: 大森, 景介
• 著者標目: 大森, 景介
• 出版事項: MDPI
• 出版年月日等: 2022-12-07
• 出版年（W3CDTF）: 2022-12-07
• 並列タイトル等: 骨粗鬆症治療患者に生じた薬剤関連顎骨壊死の治療における骨吸収抑制薬休薬の無効性：免疫組織学的所見および治療成績からの考察
• タイトル（掲載誌）: International Journal of Environmental Research and Public Health
• 巻号年月日等（掲載誌）: 19 17
• 掲載巻: 19
• 掲載号: 17
• 掲載ページ: 10898-
• ISSN（掲載誌）: ISSN : 1660-4601
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2022-12-07
• 報告番号: 甲医歯薬第1477号
• 学位: 博士(歯学)
• 本文の言語コード: eng
• 件名標目: antiresorptive agents; bisphosphonate; denosumab; drug holiday; osteoclast suppression
• 対象利用者: 一般
• 一般注記: In patients with osteoporosis receiving antiresorptive agents (ARs), it has been widely practiced to withdraw ARs for several months before tooth extraction and during treatment if medication-related osteonecrosis of the jaw (MRONJ) develops. This study examined the effects of drug holidays on recovery from osteoclast suppression and the treatment outcomes. The relationship between the period of the drug holidays and treatment outcomes was examined retrospectively in 166 osteoporosis patients with MRONJ who received ARs. Histological examinations using hematoxylin and eosin staining and cathepsin K stains were performed to observe the recovery from osteoclast suppression in 43 patients in whom living bone was observed in the resection margins of the surgical specimens. Three-month AR drug holidays were not significantly correlated with the treatment outcomes of the 139 patients who underwent surgical treatment and the 27 who underwent conservative treatment. Of the 43 patients who underwent histological investigations, 16 had drug holidays from 7 to 678 days. Osteoclast suppression was observed in almost all patients, except in one without a drug holiday and one with a 261-day drug holiday. These findings suggest that AR drug holidays for approximately 3 months neither recover osteoclast suppression nor affect treatment outcomes.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1477号 学位授与年月日:令和4年12月7日; Author: Keisuke Omori, Mitsunobu Otsuru, Kota Morishita, Saki Hayashida, Koki Suyama, Tomofumi Naruse, Sakiko Soutome and Masahiro Umeda; Citation: International Journal of Environmental Research and Public Health, 19(17), art.no. 10898; 202210.3390/ijerph191710898; identifier:Nagasaki University (長崎大学), 博士(歯学) (2022-12-07)
• 一次資料へのリンクURL: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27897&item_no=1&attribute_id=70&file_no=1 （fulltext）; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27897&item_no=1&attribute_id=70&file_no=1
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• 関連情報: http://hdl.handle.net/10069/00041984
• 関連情報（DOI）: 10.3390/ijerph191710898
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 長崎大学 : 長崎大学学術研究成果リポジトリ