Ineffectiveness of Antiresorptive Agent Drug Holidays in Osteoporosis Patients for Treatment of Medication-Related Osteonecrosis of the Jaw: Consideration from Immunohistological Observation of Osteoclast Suppression and Treatment Outcomes

• Material Type: 博士論文
• Title: Ineffectiveness of Antiresorptive Agent Drug Holidays in Osteoporosis Patients for Treatment of Medication-Related Osteonecrosis of the Jaw: Consideration from Immunohistological Observation of Osteoclast Suppression and Treatment Outcomes
• Author/Editor: 大森, 景介
• Author Heading: 大森, 景介
• Publication, Distribution, etc.: MDPI
• Publication Date: 2022-12-07
• Publication Date (W3CDTF): 2022-12-07
• Alternative Title: 骨粗鬆症治療患者に生じた薬剤関連顎骨壊死の治療における骨吸収抑制薬休薬の無効性：免疫組織学的所見および治療成績からの考察
• Periodical title: International Journal of Environmental Research and Public Health
• No. or year of volume/issue: 19 17
• Volume: 19
• Issue: 17
• Pages: 10898-
• ISSN (Periodical Title): ISSN : 1660-4601
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2022-12-07
• Dissertation Number: 甲医歯薬第1477号
• Degree Type: 博士(歯学)
• Text Language Code: eng
• Subject Heading: antiresorptive agents; bisphosphonate; denosumab; drug holiday; osteoclast suppression
• Target Audience: 一般
• Note (General): In patients with osteoporosis receiving antiresorptive agents (ARs), it has been widely practiced to withdraw ARs for several months before tooth extraction and during treatment if medication-related osteonecrosis of the jaw (MRONJ) develops. This study examined the effects of drug holidays on recovery from osteoclast suppression and the treatment outcomes. The relationship between the period of the drug holidays and treatment outcomes was examined retrospectively in 166 osteoporosis patients with MRONJ who received ARs. Histological examinations using hematoxylin and eosin staining and cathepsin K stains were performed to observe the recovery from osteoclast suppression in 43 patients in whom living bone was observed in the resection margins of the surgical specimens. Three-month AR drug holidays were not significantly correlated with the treatment outcomes of the 139 patients who underwent surgical treatment and the 27 who underwent conservative treatment. Of the 43 patients who underwent histological investigations, 16 had drug holidays from 7 to 678 days. Osteoclast suppression was observed in almost all patients, except in one without a drug holiday and one with a 261-day drug holiday. These findings suggest that AR drug holidays for approximately 3 months neither recover osteoclast suppression nor affect treatment outcomes.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1477号 学位授与年月日:令和4年12月7日; Author: Keisuke Omori, Mitsunobu Otsuru, Kota Morishita, Saki Hayashida, Koki Suyama, Tomofumi Naruse, Sakiko Soutome and Masahiro Umeda; Citation: International Journal of Environmental Research and Public Health, 19(17), art.no. 10898; 202210.3390/ijerph191710898; identifier:Nagasaki University (長崎大学), 博士(歯学) (2022-12-07)
• Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27897&item_no=1&attribute_id=70&file_no=1 （fulltext）; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27897&item_no=1&attribute_id=70&file_no=1
• Access Restrictions: インターネット公開
• Rights (production): © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• Related Material: http://hdl.handle.net/10069/00041984
• Related Material (DOI): 10.3390/ijerph191710898
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ