2,2',3,4',5,5'-六塩素化ビフェニル(CB146)のin vitro代謝の動物種差(油症とPCB及びダイオキシン関連化合物に関する研究報告集(第24集))

• 資料種別: 記事
• タイトル: 2,2',3,4',5,5'-六塩素化ビフェニル(CB146)のin vitro代謝の動物種差
• 著者・編者: 太田 千穂; 原口 浩一; 加藤 善久 他
• シリーズタイトル: 油症とPCB及びダイオキシン関連化合物に関する研究報告集(第24集)
• 著者標目: 太田 千穂; 原口 浩一; 加藤 善久
• 並列タイトル等: Species Difference in the Metabolism of 2,2',3,4',5,5'-Hexachlorobiphenyl (CB146) by Animal and Human Liver Microsomes
• タイトル（掲載誌）: 福岡医学雑誌 = Fukuoka acta medica
• 巻号年月日等（掲載誌）: 104(4)=1099:2013.4.25
• 掲載巻: 104
• 掲載号: 4
• 掲載通号: 1099
• 掲載ページ: 161-169
• 掲載年月日（W3CDTF）: 2013-04-25
• ISSN（掲載誌）: 0016-254X
• ISSN-L（掲載誌）: 0016-254X
• 出版事項（掲載誌）: 福岡 : 福岡医学会
• 出版地（国名コード）: JP
• 本文の言語コード: jpn
• 件名標目: CB146; Metabolism; Cytochrome P450; Rat; Human
• NDLC: ZS7
• 対象利用者: 一般
• 所蔵機関: 国立国会図書館
• 請求記号: Z19-86
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 024893869; http://id.ndl.go.jp/bib/024893869
• 整理区分コード: 632

• 要約等: The in vitro metabolism of 2, 2', 3, 4', 5, 5'-hexachlorobiphenyl (hexaCB) (CB146) was examined using liver microsomes of rats, guinea pigs, hamsters and human. Untreated animal livers produced one metabolite (M-2) in rats, three metabolites (M-1, M-2 and M-3) in guinea pigs and no metabolite in hamsters. Pretreatment of phenobarbital (PB) resulted in a marked increase of M-1 in three animals and of M-2 in guinea pigs. In contrast, pretreatment of 3-methylcholanthrene showed a significant increase of M-3 in guinea pigs and a decrease of M-2 in rats. Human liver microsomes prepared from nine Caucasians mainly formed M-2 and M-3 at a ratio of 2 : 1 and two individuals also formed one more metabolite M-1. The formation of M-1 was significantly correlated with CYP2B6 activity. By comparison of the GC-MS data of three metabolites with synthesized authentic samples, M-1 and M-2 were determined to be 3'-hydroxy (OH) -CB146 and 4-OH-CB146, respectively. However, M-3 is unclear at present except the fact that it is OH-hexaCB. These results suggest that 3'-OH-CB146 is formed by PB-inducible cytochrome P450 (CYP2B enzymes) in animal and human livers and 4-OH-CB146 is a major metabolite in rat and human liver.
• DOI: 10.15017/26707; https://doi.org/10.15017/26707
• オンライン閲覧公開範囲: インターネット公開
• 掲載誌（NCID）: AN00215478; https://ci.nii.ac.jp/ncid/AN00215478
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 九州大学学術情報リポジトリ(QIR); https://www.lib.kyushu-u.ac.jp/papers

• 要約等: The in vitro metabolism of 2, 2', 3, 4', 5, 5'-hexachlorobiphenyl (hexaCB) (CB146) was examined using liver microsomes of rats, guinea pigs, hamsters and human. Untreated animal livers produced one metabolite (M-2) in rats, three metabolites (M-1, M-2 and M-3) in guinea pigs and no metabolite in hamsters. Pretreatment of phenobarbital (PB) resulted in a marked increase of M-1 in three animals and of M-2 in guinea pigs. In contrast, pretreatment of 3-methylcholanthrene showed a significant increase of M-3 in guinea pigs and a decrease of M-2 in rats. Human liver microsomes prepared from nine Caucasians mainly formed M-2 and M-3 at a ratio of 2 : 1 and two individuals also formed one more metabolite M-1. The formation of M-1 was significantly correlated with CYP2B6 activity. By comparison of the GC-MS data of three metabolites with synthesized authentic samples, M-1 and M-2 were determined to be 3'-hydroxy (OH) -CB146 and 4-OH-CB146, respectively. However, M-3 is unclear at present except the fact that it is OH-hexaCB. These results suggest that 3'-OH-CB146 is formed by PB-inducible cytochrome P450 (CYP2B enzymes) in animal and human livers and 4-OH-CB146 is a major metabolite in rat and human liver.
• DOI: 10.15017/26707; https://doi.org/10.15017/26707
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（URI）: https://hdl.handle.net/2324/26707; http://id.ndl.go.jp/bib/024893869; https://ndlsearch.ndl.go.jp/books/R000000004-I024893869; https://search.jamas.or.jp/link/ui/2013355672
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 学術機関リポジトリデータベース; https://irdb.nii.ac.jp; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; PubMed; https://pubmed.ncbi.nlm.nih.gov; CiNii Articles; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja
• 書誌ID（NDLBibID）: 024893869; http://id.ndl.go.jp/bib/024893869
• NII論文ID: 120005303404