並列タイトル等Morphometric demonstration of portal vein stenosis and hepatic arterial medial hypertrophy in patients with biliary atresia.
タイトル（掲載誌）Pediatric Surgery International
学位博士(医学)
Doctor of Philosophy in Medical Science
一般注記博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Purpose: Portal hypertension in patients with biliary atresia (BA) is generally thought to result from portal vein (PV) narrowing secondary to hepatic fibrosis. To test the hypothesis, we morphometrically analyzed the PVs and hepatic arteries (HAs).
Methods: Morphometrical analyses of 25 BA and 26 non-BA liver biopsy specimens from patients treated from 2000 to 2014. The total specimen area, the fibrotic portal area, vessel diameter and medial thickness of the HAs were measured.
Results: The PV diameter in BA patients was significantly smaller than that in non-BA patients. In BA, the numbers of normal-sized PVs and capillaries were decreased and increased, respectively. The PV diameter was not significantly correlated with the degree of fibrosis. We newly found that medial hypertrophy and the HA diameter increased with the number of endothelial cells in BA. The PV diameter was not significantly correlated with the medial thickness and was positively correlated with the HA diameter in BA.
Conclusions: The narrowing of the PV is unlikely to occur secondarily to liver fibrosis. The medial hypertrophy of the HA is not correlated with the decrease in the PV blood flow. These findings seem to be unique to the primary vascular lesions of BA.
Ryuta Masuya, Toshihiro Muraji, Haruo Ohtani, Motoi Mukai, Shun Onishi, Toshio Harumatsu, Koji Yamada, Waka Yamada, Takafumi Kawano, Seiro Machigashira, Kazuhiko Nakame, Tatsuru Kaji & Satoshi Ieiri
Morphometric demonstration of portal vein stenosis and hepatic arterial medial hypertrophy in patients with biliary atresia
Pediatric Surgery International(2019), 35, 529–537
This is a post-peer-review, pre-copyedit version of an article published in Pediatric Surgery International.
The final authenticated version is available online at:
https://doi.org/10.1007/s00383-019-04459-4.
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）