胆道閉鎖症の肝生検検体における門脈および肝動脈の形態計測学的検討

• Material Type: 博士論文
• Title: 胆道閉鎖症の肝生検検体における門脈および肝動脈の形態計測学的検討
• Author/Editor: 桝屋, 隆太
• Author Heading: 桝屋, 隆太 マスヤ, リュウタ
• Publication, Distribution, etc.: Springer
• Publication Date: 2019
• Publication Date (W3CDTF): 2019
• Alternative Title: Morphometric demonstration of portal vein stenosis and hepatic arterial medial hypertrophy in patients with biliary atresia.
• Periodical title: Pediatric Surgery International
• No. or year of volume/issue: 35
• Volume: 35
• Pages: 529-537
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-03-25
• Dissertation Number: 甲総研第500号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: Biliary atresia; Portal vein; Hepatic artery; Morphometrical analysis
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Purpose: Portal hypertension in patients with biliary atresia (BA) is generally thought to result from portal vein (PV) narrowing secondary to hepatic fibrosis. To test the hypothesis, we morphometrically analyzed the PVs and hepatic arteries (HAs). Methods: Morphometrical analyses of 25 BA and 26 non-BA liver biopsy specimens from patients treated from 2000 to 2014. The total specimen area, the fibrotic portal area, vessel diameter and medial thickness of the HAs were measured. Results: The PV diameter in BA patients was significantly smaller than that in non-BA patients. In BA, the numbers of normal-sized PVs and capillaries were decreased and increased, respectively. The PV diameter was not significantly correlated with the degree of fibrosis. We newly found that medial hypertrophy and the HA diameter increased with the number of endothelial cells in BA. The PV diameter was not significantly correlated with the medial thickness and was positively correlated with the HA diameter in BA. Conclusions: The narrowing of the PV is unlikely to occur secondarily to liver fibrosis. The medial hypertrophy of the HA is not correlated with the decrease in the PV blood flow. These findings seem to be unique to the primary vascular lesions of BA. Ryuta Masuya, Toshihiro Muraji, Haruo Ohtani, Motoi Mukai, Shun Onishi, Toshio Harumatsu, Koji Yamada, Waka Yamada, Takafumi Kawano, Seiro Machigashira, Kazuhiko Nakame, Tatsuru Kaji & Satoshi Ieiri Morphometric demonstration of portal vein stenosis and hepatic arterial medial hypertrophy in patients with biliary atresia Pediatric Surgery International(2019), 35, 529–537 This is a post-peer-review, pre-copyedit version of an article published in Pediatric Surgery International. The final authenticated version is available online at: https://doi.org/10.1007/s00383-019-04459-4.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_Masaya_Ryuta_isk_500 other

Comments_Masuya_Ryuta_isk_500 other

Diss_桝屋_隆太_ISK500_2018 fulltext

Abstract_桝屋_隆太_4515800128_2018 abstract