Strong adhesiveness of a new biodegradable hydrogel glue, LYDEX, for use on articular cartilage

• 資料種別: 博士論文
• タイトル: Strong adhesiveness of a new biodegradable hydrogel glue, LYDEX, for use on articular cartilage
• 著者・編者: Kazusa, Hiromi
• 著者標目: Kazusa, Hiromi
• 並列タイトル等: 自己分解性を有する生体接着剤 LYDEX の関節軟骨に対する接着性の検討
• 授与機関名: 広島大学(Hiroshima University)
• 授与年月日: 2013-11-28
• 報告番号: 甲第6268号
• 学位: 博士(医学)
• 本文の言語コード: eng
• 件名標目: Articular cartilage; Adhesive strength; Biodegradable hydrogel glue; Collagen membrane; Cytotoxity
• NDC: 490
• 対象利用者: 一般
• 一般注記: type:text; Aim: Until recently, only fibrin glue has been available for clinical usage to repair articular cartilage, although its adhesiveness is not strong enough for use with articular cartilage, and it is derived from human blood and thus carries the risk of contamination. Recently, LYDEX, a new biodegradable hydrogel glue, has come onto the market. The purpose of this study was to evaluate the adhesive strength and cytotoxicity of LYDEX when used on articular cartilage. Materials and Methods: The differing adhesive strengths of collagen membrane and articular cartilage with LYDEX versus with fibrin glue were measured using a tensile tester. In addition, the cytotoxity of LYDEX in vitro was evaluated. The cytotoxity of LYDEX for the articular cartilage of rats was evaluated histopathologically. Results: The adhesive strength of LYDEX was significantly stronger than that of fibrin glue, giving values about 3.8 times higher. LYDEX has no discernible effect on normal articular cartilage. Conclusions: Our study is the first to assess the usefulness and safety of LYDEX for use on articular cartilage.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: Copyright(c) by Author
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 広島大学 : 広島大学学術情報リポジトリ

目次

http://ir.lib.hiroshima-u.ac.jp/files/public/3/36318/20141121021012371962/k6268_3.pdf fulltext

http://ir.lib.hiroshima-u.ac.jp/files/public/3/36318/2018112711523164121/k6268_1.pdf fulltext

http://ir.lib.hiroshima-u.ac.jp/files/public/3/36318/20181127115231527760/k6268_2.pdf fulltext