Strong adhesiveness of a new biodegradable hydrogel glue, LYDEX, for use on articular cartilage

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学術機関リポジトリデータベース（IRDB）（機関リポジトリ）

Strong adhesiveness of a new biodegradable hydrogel glue, LYDEX, for use on articular cartilage

Material type: 博士論文

Author: Kazusa, Hiromi

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Publication date: -

Material Format: Digital

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Name of awarding university/degree: 広島大学(Hiroshima University),博士(医学)

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Note (General)：: type:textAim: Until recently, only fibrin glue has been available for clinical usage to repair articular cartilage, although its adhesiveness is not s...

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Material Type: 博士論文
Title: Strong adhesiveness of a new biodegradable hydrogel glue, LYDEX, for use on articular cartilage
Author/Editor: Kazusa, Hiromi
Author Heading: Kazusa, Hiromi
Alternative Title: 自己分解性を有する生体接着剤　LYDEX　の関節軟骨に対する接着性の検討
Degree grantor/type: 広島大学(Hiroshima University)
Date Granted: 2013-11-28
Dissertation Number: 甲第6268号
Degree Type: 博士(医学)
Text Language Code: eng
Subject Heading: Articular cartilage
Adhesive strength
Biodegradable hydrogel glue
Collagen membrane
Cytotoxity
NDC: 490
Target Audience: 一般
Note (General): type:text
Aim: Until recently, only fibrin glue has been available for clinical usage to repair articular cartilage, although its adhesiveness is not strong enough for use with articular cartilage, and it is derived from human blood and thus carries the risk of contamination. Recently, LYDEX, a new biodegradable hydrogel glue, has come onto the market. The purpose of this study was to evaluate the adhesive strength and cytotoxicity of LYDEX when used on articular cartilage. Materials and Methods: The differing adhesive strengths of collagen membrane and articular cartilage with LYDEX versus with fibrin glue were measured using a tensile tester. In addition, the cytotoxity of LYDEX in vitro was evaluated. The cytotoxity of LYDEX for the articular cartilage of rats was evaluated histopathologically. Results: The adhesive strength of LYDEX was significantly stronger than that of fibrin glue, giving values about 3.8 times higher. LYDEX has no discernible effect on normal articular cartilage. Conclusions: Our study is the first to assess the usefulness and safety of LYDEX for use on articular cartilage.
Format (IMT): application/pdf
Source: fulltext
http://ir.lib.hiroshima-u.ac.jp/files/public/3/36318/20141121021012371962/k6268_3.pdf
fulltext
http://ir.lib.hiroshima-u.ac.jp/files/public/3/36318/2018112711523164121/k6268_1.pdf
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http://ir.lib.hiroshima-u.ac.jp/files/public/3/36318/20181127115231527760/k6268_2.pdf
Access Restrictions: インターネット公開
Rights (production): Copyright(c) by Author
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 広島大学 : 広島大学学術情報リポジトリ