並列タイトル等発症前後のナルコレプシーモデルマウスにおける睡眠覚醒変化とカタプレキシー様行動の非侵襲的解析
一般注記Sleep and behavioral monitoring of young mice is necessary for
understating the progress of these symptoms in congenital and acquired
diseases associated with sleep and movement disorders. In the current study,
we have developed a non-invasive sleep monitoring system that identifies wake
and sleep of newborn mice using a simple piezoelectric transducer (PZT). Using
this system, we have succeeded to detect age-dependent occurrences and
changes in sleep fragmentation of orexin/ataxin-3 narcoleptic mice (a
narcoleptic mouse of model of postnatal hypocretin/orexin cell death) across the
disease onset. We also detected REM sleep/cataplexy patterns (i.e., immobility
with clear heart bests [IMHB] signals due to the flaccid posture) by the PZT
system, and found that sudden onset of REM sleep-like episodes specifically
occur in narcoleptic, but not in wild type mice, suggesting that these episodes
are likely to be cataplexy. In contrast, gradual onset of IMHB likely to reflect
occurrence of REM sleep.
In summary, we have shown that the PZT system is useful as a noninvasive
sleep and behavior monitoring system to analyze the developmental
aspects of sleep and movement disorders in mice models.
関連情報（DOI）10.1016/j.expneurol.2014.08.004
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）