Noninvasive detection of sleep/wake changes and cataplexy -like behaviors in orexin/ataxin-3 transgenicnarcoleptic mice across the disease onset

• Material Type: 博士論文
• Title: Noninvasive detection of sleep/wake changes and cataplexy -like behaviors in orexin/ataxin-3 transgenicnarcoleptic mice across the disease onset
• Author/Editor: 佐藤, 雅俊; SATO, Masatoshi
• Author Heading: 佐藤, 雅俊; SATO, Masatoshi
• Publication, Distribution, etc.: 秋田大学
• Publication Date: 2015-06-01
• Publication Date (W3CDTF): 2015-06-01
• Alternative Title: 発症前後のナルコレプシーモデルマウスにおける睡眠覚醒変化とカタプレキシー様行動の非侵襲的解析
• Degree grantor/type: 秋田大学
• Date Granted: 2015-03-22
• Dissertation Number: 甲第1110号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Sleep and behavioral monitoring of young mice is necessary for understating the progress of these symptoms in congenital and acquired diseases associated with sleep and movement disorders. In the current study, we have developed a non-invasive sleep monitoring system that identifies wake and sleep of newborn mice using a simple piezoelectric transducer (PZT). Using this system, we have succeeded to detect age-dependent occurrences and changes in sleep fragmentation of orexin/ataxin-3 narcoleptic mice (a narcoleptic mouse of model of postnatal hypocretin/orexin cell death) across the disease onset. We also detected REM sleep/cataplexy patterns (i.e., immobility with clear heart bests [IMHB] signals due to the flaccid posture) by the PZT system, and found that sudden onset of REM sleep-like episodes specifically occur in narcoleptic, but not in wild type mice, suggesting that these episodes are likely to be cataplexy. In contrast, gradual onset of IMHB likely to reflect occurrence of REM sleep. In summary, we have shown that the PZT system is useful as a noninvasive sleep and behavior monitoring system to analyze the developmental aspects of sleep and movement disorders in mice models.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): Elsevier
• Related Material (DOI): 10.1016/j.expneurol.2014.08.004
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 秋田大学 : 秋田大学学術情報リポジトリ

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