Pathogenic potential and growth kinetics of Muko virus in mice and human-derived cells

• 資料種別: 記事
• タイトル: Pathogenic potential and growth kinetics of Muko virus in mice and human-derived cells
• 著者・編者: Gianne Eduard L. Ulanday; Satoshi Shimada; Ngwe Tun Mya Myat
• 出版事項: 日本 : Springer Nature
• 出版年月日等: 2016-10-11
• 出版年（W3CDTF）: 2016-10-11
• タイトル（掲載誌）: Tropical medicine and health
• 巻号年月日等（掲載誌）: 44(31)
• 掲載巻: 44(31)
• ISSN（掲載誌）: 1349-4147
• ISSN-L（掲載誌）: 1348-8945
• 本文の言語コード: eng
• DOI: 10.1186/s41182-016-0032-7; https://doi.org/10.1186/s41182-016-0032-7
• 国立国会図書館永続的識別子: info:ndljp/pid/10233116; https://dl.ndl.go.jp/pid/10233116
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• 収集根拠: オンライン資料収集制度
• 受理日（W3CDTF）: 2016-12-28T13:40:57+09:00
• 保存日（W3CDTF）: 2016-12-26
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://tropmedhealth.biomedcentral.com/articles
• 掲載誌（国立国会図書館永続的識別子）: info:ndljp/pid/10233085; https://dl.ndl.go.jp/pid/10233085
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• 要約等: Background: Ticks have been long known as vectors of various pathogens, some of which can cause high fatality rates among infected individuals. Our enhanced tick surveillance around Nagasaki, Japan, led to the isolation and identification of a new strain of a recently identified Orbivirus, Muko virus (MUV). The orbiviruses have a wide host range, including humans, and is related to a spectrum of clinical outcomes. However, the zoonotic potential of some members of the genus, although reported, were not clearly elucidated. Hence, it is imperative to characterize newly isolated orbiviruses and investigate its ability to endanger public health. Methods: In this study, we explored the in vivo pathogenicity of a newly isolated MUV strain (MUV-Hay) using a mouse model and demonstrated its growth kinetics in human-derived cells. Results: Our results showed the ability of MUV-Hay to propagate in human neuronal and renal cells with some cytopathic effect. Furthermore, intracerebral inoculation of our new isolate caused high mortality in adult A129 mice. Conclusion: Our study provided a first step to experimentally test the hypothesis, that MUV can replicate and produce cytopathic effect in human cells and demonstrate virulence in adult mice.; Tropical Medicine and Health, 44, 31; 2016
• DOI: 10.1186/s41182-016-0032-7; https://doi.org/10.1186/s41182-016-0032-7
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: c The Author(s) 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
• 関連情報（URI）: http://hdl.handle.net/10069/37325; https://nagasaki-u.repo.nii.ac.jp/records/2129; http://id.ndl.go.jp/digimeta/10233116; https://dl.ndl.go.jp/pid/10233116; http://link.springer.com/content/pdf/10.1186/s41182-016-0032-7.pdf; http://link.springer.com/article/10.1186/s41182-016-0032-7/fulltext.html; https://search.jamas.or.jp/link/ui/2018007043
• 参照: Seroepidemiological surveys of tick-borne encephalitis virus and novel tick-borne viruses in wild boar in Nagasaki, Japan; https://cir.nii.ac.jp/crid/1360294643716328576
• 参照: Tofla virus : A newly identified Nairovirus of the Crimean-Congo hemorrhagic fever group isolated from ticks in Japan; https://cir.nii.ac.jp/crid/1050282812466493568; The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan; https://cir.nii.ac.jp/crid/1360002217569910912; Primer3—new capabilities and interfaces; https://cir.nii.ac.jp/crid/1360011142938856192; DIALIGN-T: An improved algorithm for segment-based multiple sequence alignment; https://cir.nii.ac.jp/crid/1360011145464870528; New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0; https://cir.nii.ac.jp/crid/1360292617907969920; Crimean-Congo hemorrhagic fever virus infection is lethal for adult type I interferon receptor-knockout mice; https://cir.nii.ac.jp/crid/1360574095199014784; Experimental Studies on the Transmission Cycle of Thogoto Virus, a Candidate Orthomyxovirus, in Rhipicephalus appendiculatus; https://cir.nii.ac.jp/crid/1360574095879292928; A Review of Knowledge Gaps and Tools for Orbivirus Research; https://cir.nii.ac.jp/crid/1360855569915549184; Detection of Severe Fever with Thrombocytopenia Syndrome Virus from Wild Animals and Ixodidae Ticks in the Republic of Korea; https://cir.nii.ac.jp/crid/1360855570347832192; Hazara virus infection is lethal for adult type I interferon receptor-knockout mice and may act as a surrogate for infection with the human-pathogenic Crimean–Congo hemorrhagic fever virus; https://cir.nii.ac.jp/crid/1361137045804485760; Ecology of the Tick-Borne Phlebovirus Causing Severe Fever with Thrombocytopenia Syndrome in an Endemic Area of China; https://cir.nii.ac.jp/crid/1361137046162626560; The Ecology, Genetic Diversity, and Phylogeny of Huaiyangshan Virus in China; https://cir.nii.ac.jp/crid/1361137046529706112; First Isolations of Barur Virus (Rhabdoviridae) from Ticks (Acari: Ixodidae) in Africa; https://cir.nii.ac.jp/crid/1361418519363126272; No Detection of Severe Fever with Thrombocytopenia Syndrome Virus from Ixodid Ticks Collected in Seoul; https://cir.nii.ac.jp/crid/1361418519801936640; Isolation of Tick-Borne Encephalitis Virus from Ixodes ovatus (Acari: Ixodidae) in Japan; https://cir.nii.ac.jp/crid/1361418520864809856; Tick-borne viruses: A review from the perspective of therapeutic approaches; https://cir.nii.ac.jp/crid/1362262945704786816; ProtTest 3: fast selection of best-fit models of protein evolution; https://cir.nii.ac.jp/crid/1362544420766239744; Detection of SFTS Virus in<i>Ixodes nipponensis</i>and<i>Amblyomma testudinarium</i>(Ixodida: Ixodidae) Collected From Reptiles in the Republic of Korea; https://cir.nii.ac.jp/crid/1362825894545092352; Host and Potential Vector Susceptibility to an Emerging Orbivirus in the United States; https://cir.nii.ac.jp/crid/1363107368373252992; First Isolation of Severe Fever with Thrombocytopenia Syndrome Virus from <i>Haemaphysalis longicornis</i> Ticks Collected in Severe Fever with Thrombocytopenia Syndrome Outbreak Areas in the Republic of Korea; https://cir.nii.ac.jp/crid/1363107369455230464; <i>Haemaphysalis longicornis</i>Ticks as Reservoir and Vector of Severe Fever with Thrombocytopenia Syndrome Virus in China; https://cir.nii.ac.jp/crid/1363670318596150144; A case of tick-borne encephalitis in Japan and isolation of the the virus; https://cir.nii.ac.jp/crid/1363670320194633600; DIALIGN-TX: greedy and progressive approaches for segment-based multiple sequence alignment; https://cir.nii.ac.jp/crid/1363951793489162624; Bunyaviridae; https://cir.nii.ac.jp/crid/1363951795526391936; Prevalence of severe fever with thrombocytopenia syndrome virus in Haemaphysalis longicornis ticks in South Korea; https://cir.nii.ac.jp/crid/1364233269003678208; trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses; https://cir.nii.ac.jp/crid/1364233269941863040; Enhancements and modifications of primer design program Primer3; https://cir.nii.ac.jp/crid/1364233269991245440; Genetic and biological characterization of Muko virus, a new distinct member of the species Great Island virus (genus Orbivirus, family Reoviridae), isolated from ixodid ticks in Japan; https://cir.nii.ac.jp/crid/1364233271289398016; Epidemiological Survey of Severe Fever with Thrombocytopenia Syndrome Virus in Ticks in Nagasaki, Japan; https://cir.nii.ac.jp/crid/1390001205219445120
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: 学術機関リポジトリデータベース; https://irdb.nii.ac.jp; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org; CiNii Articles; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja
• 書誌ID（NDLBibID）: 10233116; http://id.ndl.go.jp/bib/10233116
• NII論文ID: 120006987624

• DOI: 10.15080/chitoka.60.0_35; https://doi.org/10.15080/chitoka.60.0_35
• 関連情報（URI）: http://id.ndl.go.jp/bib/10233116; https://ndlsearch.ndl.go.jp/books/R000000004-I10233116
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; CiNii Articles
• 書誌ID（NDLBibID）: 10233116; http://id.ndl.go.jp/bib/10233116
• NII論文ID: 110007230550