Pathogenic potential and growth kinetics of Muko virus in mice and human-derived cells

• Material Type: 記事
• Title: Pathogenic potential and growth kinetics of Muko virus in mice and human-derived cells
• Author/Editor: Gianne Eduard L. Ulanday; Satoshi Shimada; Ngwe Tun Mya Myat
• Publication, Distribution, etc.: 日本 : Springer Nature
• Publication Date: 2016-10-11
• Publication Date (W3CDTF): 2016-10-11
• Periodical title: Tropical medicine and health
• No. or year of volume/issue: 44(31)
• Volume: 44(31)
• ISSN (Periodical Title): 1349-4147
• ISSN-L (Periodical Title): 1348-8945
• Text Language Code: eng
• DOI: 10.1186/s41182-016-0032-7; https://doi.org/10.1186/s41182-016-0032-7
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• Acquisition Basis: オンライン資料収集制度
• Date Accepted (W3CDTF): 2016-12-28T13:40:57+09:00
• Date Captured (W3CDTF): 2016-12-26
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• Summary, etc.: Background: Ticks have been long known as vectors of various pathogens, some of which can cause high fatality rates among infected individuals. Our enhanced tick surveillance around Nagasaki, Japan, led to the isolation and identification of a new strain of a recently identified Orbivirus, Muko virus (MUV). The orbiviruses have a wide host range, including humans, and is related to a spectrum of clinical outcomes. However, the zoonotic potential of some members of the genus, although reported, were not clearly elucidated. Hence, it is imperative to characterize newly isolated orbiviruses and investigate its ability to endanger public health. Methods: In this study, we explored the in vivo pathogenicity of a newly isolated MUV strain (MUV-Hay) using a mouse model and demonstrated its growth kinetics in human-derived cells. Results: Our results showed the ability of MUV-Hay to propagate in human neuronal and renal cells with some cytopathic effect. Furthermore, intracerebral inoculation of our new isolate caused high mortality in adult A129 mice. Conclusion: Our study provided a first step to experimentally test the hypothesis, that MUV can replicate and produce cytopathic effect in human cells and demonstrate virulence in adult mice.; Tropical Medicine and Health, 44, 31; 2016
• DOI: 10.1186/s41182-016-0032-7; https://doi.org/10.1186/s41182-016-0032-7
• Access Restrictions: インターネット公開
• Rights (production): c The Author(s) 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
• Related Material (URI): http://hdl.handle.net/10069/37325; https://nagasaki-u.repo.nii.ac.jp/records/2129; http://id.ndl.go.jp/digimeta/10233116; https://dl.ndl.go.jp/pid/10233116; http://link.springer.com/content/pdf/10.1186/s41182-016-0032-7.pdf; http://link.springer.com/article/10.1186/s41182-016-0032-7/fulltext.html; https://search.jamas.or.jp/link/ui/2018007043
• Is Referenced By: Seroepidemiological surveys of tick-borne encephalitis virus and novel tick-borne viruses in wild boar in Nagasaki, Japan; https://cir.nii.ac.jp/crid/1360294643716328576
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• Bibliographic ID (NDL): 10233116; http://id.ndl.go.jp/bib/10233116
• NAID: 120006987624

• DOI: 10.15080/chitoka.60.0_35; https://doi.org/10.15080/chitoka.60.0_35
• Related Material (URI): http://id.ndl.go.jp/bib/10233116; https://ndlsearch.ndl.go.jp/books/R000000004-I10233116
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• Bibliographic ID (NDL): 10233116; http://id.ndl.go.jp/bib/10233116
• NAID: 110007230550