Formulation for effective screening and management of nonalcoholic steatohepatitis Noninvasive NAFLD management strategy

• 資料種別: 博士論文
• タイトル: Formulation for effective screening and management of nonalcoholic steatohepatitis Noninvasive NAFLD management strategy
• 著者・編者: Hirose, Kanae
• 出版事項: 新潟大学
• 出版年月日等: 2016-09-20
• 出版年（W3CDTF）: 2016-09-20
• 並列タイトル等: Formulation for effective screening and management of nonalcoholic steatohepatitis Noninvasive NAFLD management strategy; 非アルコール性脂肪肝炎の効果的なスクリーニングとマネジメント、非侵襲的なNAFLD管理の方法
• 授与機関名: 新潟大学
• 授与年月日: 2016-09-20
• 授与年月日（W3CDTF）: 2016-09-20
• 報告番号: 甲第4207号
• 学位: 博士（医学）
• 博論授与番号: 甲第4207号
• 本文の言語コード: eng
• 件名標目: nonalcoholic fatty liver disease; screening; shear wave velocity; formula
• 一般注記: To establish a versatile means for screening and management of nonalcoholic steatohepatitis (NASH), shear wave velocity was measured in 20 normal controls and 138 consecutive nonalcoholic fatty liver disease (NAFLD) cases. Referencing biochemical properties in 679 healthy volunteers, a formula to distinguish NASH suspects was established and validated in another cohort of 138 histologically proven NAFLD cases. NASH and simple steatosis (SS)\ suspects were selected based on a plot of shear wave velocity against age. A formula consisting of five factors (ɤ-glutamyl transpeptidase, alkaline phosphatase, platelet counts, body mass index, and presence/absence of type 2 diabetes mellitus) distinguished NASH suspects from SS suspects with area under the receiver operating characteristic curve values of 86% and 84% in the development and validation cohorts. Among 25 NAFLD cases in which shear wave velocity was repeatedly measured, 8 and 9 cases revealed an increase or decrease, respectively, of shear wave velocity in the entire liver, and the corresponding change in shear wave velocity was primarily observed in the right lobe or the left lateral segment, respectively. These results suggest that the new formula and sequential shear wave velocity measurements at each segment enable high throughput screening of NASH suspects and oninvasive assessment of pathophysiological alleviation/aggravation in cases of NASH.; 学位の種類: 博士（医学）. 報告番号: 甲第4207号. 学位記番号: 新大院博（医）甲第706号. 学位授与年月日: 平成28年9月20日; 新大院博（医）甲第706号
• 国立国会図書館永続的識別子: info:ndljp/pid/10233370; https://dl.ndl.go.jp/pid/10233370
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-01-01T19:17:28+09:00
• 作成日（W3CDTF）: 2019-08-05
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10191/45093
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp