Formulation for effective screening and management of nonalcoholic steatohepatitis Noninvasive NAFLD management strategy

Persistent ID (NDL): info:ndljp/pid/10233370

Material type: 博士論文

Author: Hirose, Kanae

Publisher: 新潟大学

Publication date: 2016-09-20

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: To establish a versatile means for screening and management of nonalcoholic steatohepatitis (NASH), shear wave velocity was measured in 20 normal cont...

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Material Type: 博士論文
Title: Formulation for effective screening and management of nonalcoholic steatohepatitis Noninvasive NAFLD management strategy
Author/Editor: Hirose, Kanae
Publication, Distribution, etc.: 新潟大学
Publication Date: 2016-09-20
Publication Date (W3CDTF): 2016-09-20
Alternative Title: Formulation for effective screening and management of nonalcoholic steatohepatitis Noninvasive NAFLD management strategy
非アルコール性脂肪肝炎の効果的なスクリーニングとマネジメント、非侵襲的なNAFLD管理の方法
Degree grantor/type: 新潟大学
Date Granted: 2016-09-20
Date Granted (W3CDTF): 2016-09-20
Dissertation Number: 甲第4207号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第4207号
Text Language Code: eng
Subject Heading: nonalcoholic fatty liver disease
screening
shear wave velocity
formula
Note (General): To establish a versatile means for screening and management of nonalcoholic steatohepatitis (NASH), shear wave velocity was measured in 20 normal controls and 138 consecutive nonalcoholic fatty liver disease (NAFLD) cases. Referencing biochemical properties in 679 healthy volunteers, a formula to distinguish NASH suspects was established and validated in another cohort of 138 histologically proven NAFLD cases. NASH and simple steatosis (SS)\ suspects were selected based on a plot of shear wave velocity against age. A formula consisting of five factors (ɤ-glutamyl transpeptidase, alkaline phosphatase, platelet counts, body mass index, and presence/absence of type 2 diabetes mellitus) distinguished NASH suspects from SS suspects with area under the receiver operating characteristic curve values of 86% and 84% in the development and validation cohorts. Among 25 NAFLD cases in which shear wave velocity was repeatedly measured, 8 and 9 cases revealed an increase or decrease, respectively, of shear wave velocity in the entire liver, and the corresponding change in shear wave velocity was primarily observed in the right lobe or the left lateral segment, respectively. These results suggest that the new formula and sequential shear wave velocity measurements at each segment enable high throughput screening of NASH suspects and oninvasive assessment of pathophysiological alleviation/aggravation in cases of NASH.
学位の種類: 博士（医学）. 報告番号: 甲第4207号. 学位記番号: 新大院博（医）甲第706号. 学位授与年月日: 平成28年9月20日
新大院博（医）甲第706号
Persistent ID (NDL): info:ndljp/pid/10233370
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Collection: 障害者向け資料
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Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2017-01-01T19:17:28+09:00
Date Created (W3CDTF): 2019-08-05
Format (IMT): application/pdf
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Periodical Title (URI): http://hdl.handle.net/10191/45093
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