Default mode network abnormalities in children with autism spectrum disorder detected by resting-state functional magnetic resonance imaging

• 資料種別: 博士論文
• ISSN: 1349-6867
• タイトル: Default mode network abnormalities in children with autism spectrum disorder detected by resting-state functional magnetic resonance imaging
• 巻次・部編番号: 63 3-4
• 著者・編者: Funakoshi, Yasuhiro; Harada, Masafumi; Otsuka, Hideki; Mori, Kenji; Ito, Hiromichi; Iwanaga, Takashi
• 著者標目: Funakoshi, Yasuhiro; Harada, Masafumi; Otsuka, Hideki; Mori, Kenji; Ito, Hiromichi; Iwanaga, Takashi
• 出版事項: Faculty of Medicine Tokushima University
• 出版年月日等: 2016-08
• 出版年（W3CDTF）: 2016-08
• 並列タイトル等: resting state functional MRIによる自閉性障害若年者におけるdefault mode networkの変化に関する検討; Alteration of default mode network in children with autism spectrum disorder
• タイトル（掲載誌）: The Journal of Medical Investigation
• 授与機関名: 徳島大学
• 授与年月日: 2016-12-15
• 授与年月日（W3CDTF）: 2016-12-15
• 報告番号: 甲第3004号
• 学位: 博士（保健学）
• 博論授与番号: 甲第3004号
• 本文の言語コード: eng
• 件名標目: default mode network; resting state MRI; autism spectrum disorder; interior parietal lobule; posterior cingulate cortex; development
• 対象利用者: 一般
• 一般注記: Purpose : The purpose of this study was to investigate changes in the functional connectivity of the default mode network (DMN) in normal aging and in children with autistic spectrum disorder (ASD) by using resting-state functional magnetic resonance imaging (rsfMRI) and independent component analysis. Methods : Thirty-one healthy controls (HC) in four age groups (1-3, 4-8, 20-29, and 50-59 years) and 14 childhood ASD cases (1-8 years of age) were examined by rsfMRI echo-planar imaging on a clinical 3-T MRI scanner. Imaging of all children (1-8 years) was conducted under sedation, while adults were scanned in the awake state with eyes closed. Results : The regions of DMN functional connectivity in the bilateral inferior parietal lobule and posterior cingulate cortex were smaller in HC children than in HC adults, and smaller in the ASD group than in the HC children. Conclusion : It is possible to observe developmental and pathological changes in the DMN by rsfMRI. Reduced DMN functional connectivity in children may be a useful biomarker for ASD diagnosis.
• DOI: info:doi/10.2152/jmi.63.204; https://doi.org/info:doi/10.2152/jmi.63.204
• 国立国会図書館永続的識別子: info:ndljp/pid/10300485; https://dl.ndl.go.jp/pid/10300485
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-02-09T20:08:30+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://repo.lib.tokushima-u.ac.jp/111182
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

目次

2019-09-04 再収集