Default mode network abnormalities in children with autism spectrum disorder detected by resting-state functional magnetic resonance imaging

• Material Type: 博士論文
• ISSN: 1349-6867
• Title: Default mode network abnormalities in children with autism spectrum disorder detected by resting-state functional magnetic resonance imaging
• Volume: 63 3-4
• Author/Editor: Funakoshi, Yasuhiro; Harada, Masafumi; Otsuka, Hideki; Mori, Kenji; Ito, Hiromichi; Iwanaga, Takashi
• Author Heading: Funakoshi, Yasuhiro; Harada, Masafumi; Otsuka, Hideki; Mori, Kenji; Ito, Hiromichi; Iwanaga, Takashi
• Publication, Distribution, etc.: Faculty of Medicine Tokushima University
• Publication Date: 2016-08
• Publication Date (W3CDTF): 2016-08
• Alternative Title: resting state functional MRIによる自閉性障害若年者におけるdefault mode networkの変化に関する検討; Alteration of default mode network in children with autism spectrum disorder
• Periodical title: The Journal of Medical Investigation
• Degree grantor/type: 徳島大学
• Date Granted: 2016-12-15
• Date Granted (W3CDTF): 2016-12-15
• Dissertation Number: 甲第3004号
• Degree Type: 博士（保健学）
• Conferring No. (Dissertation): 甲第3004号
• Text Language Code: eng
• Subject Heading: default mode network; resting state MRI; autism spectrum disorder; interior parietal lobule; posterior cingulate cortex; development
• Target Audience: 一般
• Note (General): Purpose : The purpose of this study was to investigate changes in the functional connectivity of the default mode network (DMN) in normal aging and in children with autistic spectrum disorder (ASD) by using resting-state functional magnetic resonance imaging (rsfMRI) and independent component analysis. Methods : Thirty-one healthy controls (HC) in four age groups (1-3, 4-8, 20-29, and 50-59 years) and 14 childhood ASD cases (1-8 years of age) were examined by rsfMRI echo-planar imaging on a clinical 3-T MRI scanner. Imaging of all children (1-8 years) was conducted under sedation, while adults were scanned in the awake state with eyes closed. Results : The regions of DMN functional connectivity in the bilateral inferior parietal lobule and posterior cingulate cortex were smaller in HC children than in HC adults, and smaller in the ASD group than in the HC children. Conclusion : It is possible to observe developmental and pathological changes in the DMN by rsfMRI. Reduced DMN functional connectivity in children may be a useful biomarker for ASD diagnosis.
• DOI: info:doi/10.2152/jmi.63.204; https://doi.org/info:doi/10.2152/jmi.63.204
• Persistent ID (NDL): info:ndljp/pid/10300485; https://dl.ndl.go.jp/pid/10300485
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-02-09T20:08:30+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://repo.lib.tokushima-u.ac.jp/111182
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2019-09-04 再収集