Long-term administration of whey alters atrophy, gene expression profiles and dysfunction of salivary glands in elderly rats

• 資料種別: 博士論文
• ISSN: 1756-4646
• タイトル: Long-term administration of whey alters atrophy, gene expression profiles and dysfunction of salivary glands in elderly rats
• 巻次・部編番号: 21
• 著者・編者: Pieczonka, Tomasz Daniel; Bragiel, Aneta M; Horikawa, Hideaki; Fukuta, Kana; Yoshioka, Masami; Ishikawa, Yasuko
• 著者標目: Pieczonka, Tomasz Daniel; Bragiel, Aneta M; Horikawa, Hideaki; Fukuta, Kana; Yoshioka, Masami; Ishikawa, Yasuko
• 出版事項: Elsevier
• 出版年月日等: 2016-01-04
• 出版年（W3CDTF）: 2016-01-04
• 並列タイトル等: ホエーの長期間摂取が老齢ラット唾液腺の萎縮、遺伝子変化、機能低下に及ぼす効果
• タイトル（掲載誌）: Journal of Functional Foods
• 授与機関名: 徳島大学
• 授与年月日: 2016-09-23
• 授与年月日（W3CDTF）: 2016-09-23
• 報告番号: 甲第2978号
• 学位: 博士（学術）
• 博論授与番号: 甲第2978号
• 本文の言語コード: eng
• 件名標目: Whey; Aging; DNA microarray; Salivary glands; Atrophy; Dysfunction
• 対象利用者: 一般
• 一般注記: Salivary glands in elderly individuals commonly exhibit morphological changes and dysfunction resulting in xerostomia. Long-term (4-week) drinking of whey prevented and/or restored age-dependent decline of salivary volume and protein concentration, and atrophy of sublingual glands (SLGs) significantly in 88-week-old rats. The transcripts of 42 genes were up-regulated and 7 genes were down-regulated by more than 1.5-fold change with FDR ≦ 0.1 after whey-drinking. The expression levels of genes associated with salivary proteins and tissue repair were significantly increased, while those associated with lipid metabolism were decreased. Venn diagram analysis revealed that expressions of 13 genes, including Tcfap2b and Abpa, were induced significantly by whey-drinking. Furthermore, secretory protein levels in SLGs and saliva were revealed by immunoblot analysis. This is the first study to report that whey-administration can prevent and/or restore age-dependent atrophy and functional decline of SLGs in relation to gene expression and thus may serve as a functional food ingredient.
• DOI: info:doi/10.1016/j.jff.2015.12.027; https://doi.org/info:doi/10.1016/j.jff.2015.12.027
• 国立国会図書館永続的識別子: info:ndljp/pid/10310723; https://dl.ndl.go.jp/pid/10310723
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-03-02T13:20:07+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/109961
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp