Long-term administration of whey alters atrophy, gene expression profiles and dysfunction of salivary glands in elderly rats

• Material Type: 博士論文
• ISSN: 1756-4646
• Title: Long-term administration of whey alters atrophy, gene expression profiles and dysfunction of salivary glands in elderly rats
• Volume: 21
• Author/Editor: Pieczonka, Tomasz Daniel; Bragiel, Aneta M; Horikawa, Hideaki; Fukuta, Kana; Yoshioka, Masami; Ishikawa, Yasuko
• Author Heading: Pieczonka, Tomasz Daniel; Bragiel, Aneta M; Horikawa, Hideaki; Fukuta, Kana; Yoshioka, Masami; Ishikawa, Yasuko
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2016-01-04
• Publication Date (W3CDTF): 2016-01-04
• Alternative Title: ホエーの長期間摂取が老齢ラット唾液腺の萎縮、遺伝子変化、機能低下に及ぼす効果
• Periodical title: Journal of Functional Foods
• Degree grantor/type: 徳島大学
• Date Granted: 2016-09-23
• Date Granted (W3CDTF): 2016-09-23
• Dissertation Number: 甲第2978号
• Degree Type: 博士（学術）
• Conferring No. (Dissertation): 甲第2978号
• Text Language Code: eng
• Subject Heading: Whey; Aging; DNA microarray; Salivary glands; Atrophy; Dysfunction
• Target Audience: 一般
• Note (General): Salivary glands in elderly individuals commonly exhibit morphological changes and dysfunction resulting in xerostomia. Long-term (4-week) drinking of whey prevented and/or restored age-dependent decline of salivary volume and protein concentration, and atrophy of sublingual glands (SLGs) significantly in 88-week-old rats. The transcripts of 42 genes were up-regulated and 7 genes were down-regulated by more than 1.5-fold change with FDR ≦ 0.1 after whey-drinking. The expression levels of genes associated with salivary proteins and tissue repair were significantly increased, while those associated with lipid metabolism were decreased. Venn diagram analysis revealed that expressions of 13 genes, including Tcfap2b and Abpa, were induced significantly by whey-drinking. Furthermore, secretory protein levels in SLGs and saliva were revealed by immunoblot analysis. This is the first study to report that whey-administration can prevent and/or restore age-dependent atrophy and functional decline of SLGs in relation to gene expression and thus may serve as a functional food ingredient.
• DOI: info:doi/10.1016/j.jff.2015.12.027; https://doi.org/info:doi/10.1016/j.jff.2015.12.027
• Persistent ID (NDL): info:ndljp/pid/10310723; https://dl.ndl.go.jp/pid/10310723
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-03-02T13:20:07+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/109961
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp