並列タイトル等日本人男性における、身長と飲酒の状況を加味した動脈硬化と高尿酸血症の関連
タイトル（掲載誌）Acta Medica Nagasakiensia
授与機関名Nagasaki University (長崎大学)
一般注記Background; Several studies have identified a positive, independent association between uric acid and atherosclerosis whereas uric acid was once considered to be a major antioxidant in human plasma with possible beneficial anti-atherosclerotic effects. Several other studies have found an inverse association between height and stroke, while a previous study of ours detected a positive association between height and hyperuricemia. However, even though uric acid levels may be strongly affected by alcohol consumption and serum creatinine, no published study has examined the possible associations between hyperuricemia and carotid atherosclerosis while taking both height and drinking status into account. Methods; We conducted a cross-sectional study of 1,337 men aged 30-89 years undergoing a general health check-up toinvestigate the associations of hyperuricemia and carotid atherosclerosis with height in relation to drinking status. Results; Of the total study population, 312 men were diagnosed with carotid atherosclerosis (carotid intima-media thickness (CIMT) ?1.1 mm) and 365 men with hyperuricemia (serum uric acid>7.0mg/dL). For shorter non-drinkers, a significantly positive association between these two abnormalities was detected, which was independent of classical cardiovascular risk factors except for serum creatinine. However, this association ceased to exist after further adjustment for serum creatinine. However, while the age-adjusted model showed no significant association for taller drinkers, adjustment for serum creatinine produced a significantly inverse association. Conclusion; Our study established that hyperuricemia is associated with carotid atherosclerosis for Japanese men, whilebody height, drinking status and serum creatinine are important determining factors for this association.
長崎大学学位論文 学位記番号:博(医歯薬)甲第917号 学位授与年月日:平成29年3月21日
Author: Shimpei Sato, Yuji Shimizu, Naomi Hayashida, Mako Nagayoshi, Jun Koyamatsu, Hirotomo Yamanashi, Koichiro Kadota, Mio Nakazato, Keita Inoue, Noboru Takamura, Yoshiyuki Oozono, Takahiro Maeda
Citation: Acta Medica Nagasakiensia, 59(3), pp.77-82; 2015
Nagasaki University (長崎大学), 博士(医学) (2017-03-21)
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