Hertwig's epithelial root sheath cells contribute to formation of periodontal ligament through epithelial-mesenchymal transition by TGF-β.

• 資料種別: 博士論文
• タイトル: Hertwig's epithelial root sheath cells contribute to formation of periodontal ligament through epithelial-mesenchymal transition by TGF-β.
• 著者・編者: Itaya, Satoshi; Oka, Kyoko; Ogata, Kayoko; Tamura, Shougo; Kira-Tatsuoka, Michiko; Fujiwara, Naoki; Otsu, Keishi; Tsuruga, Eichi; Ozaki, Masao; Harada, Hidemitsu
• 著者標目: Itaya, Satoshi; Oka, Kyoko; Ogata, Kayoko; Tamura, Shougo; Kira-Tatsuoka, Michiko; Fujiwara, Naoki; Otsu, Keishi; Tsuruga, Eichi; Ozaki, Masao; Harada, Hidemitsu
• 出版年月日等: 2017-03-11
• 出版年（W3CDTF）: 2017-03-11
• 並列タイトル等: Hertwig's epithelial root sheath cells contribute to formation of periodontal ligament through epithelial-mesenchymal transition by TGF-β.
• 授与機関名: 福岡歯科大学
• 授与年月日: 2017-03-11
• 授与年月日（W3CDTF）: 2017-03-11
• 報告番号: 甲第284号
• 学位: 博士（歯学）
• 博論授与番号: 甲第284号
• 本文の言語コード: eng
• 件名標目: ヘルトヴィッヒ上皮鞘; 上皮間葉転換; TGF-β; Hertwig's epithelial root sheath; Alkaline Phosphatase; Animals; Cadherins; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cell Line; Collagen Type I; Core Binding Factor Alpha 1 Subunit; Dental Cementum; Epithelial Cells; Epithelial-Mesenchymal Transition; Extracellular Matrix; Fibronectins; Gene Expression Regulation; Mice; Odontoblasts; Osteocalcin; Periodontal Ligament; Tooth Root; Transcription Factors; Transforming Growth Factor beta1
• 対象利用者: 一般
• 一般注記: In tooth root development, periodontal ligament (PDL) and cementum are formed by the coordination with the fragmentation of Hertwig's epithelial root sheath (HERS) and the differentiation of dental follicle mesenchymal cells. However, the function of the dental epithelial cells after HERS fragmentation in the PDL is not fully understood. Here, we found that TGF-β regulated HERS fragmentation via epithelial-mesenchymal transition (EMT), and the fragmented epithelial cells differentiated into PDL fibroblastic cells with expressing of PDL extracellular matrix (ECM). In the histochemical analysis, TGF-β was expressed in odontoblast layer adjacent of HERS during root development. Periostin expression was detected around fragmented epithelial cells on the root surface, but not in HERS. In the experiment using an established mouse HERS cell line (HERS01a), TGF-β1 treatment decreased E-cadherin and relatively increased N-cadherin expression. TGF-β1 treatment in HERS01a induced further expression of important ECM proteins for acellular cementum and PDL development such as fibronectin and periostin. Taken together, activation of TGF-βsignaling induces HERS fragmentation through EMT and the fragmented HERS cells contribute to formation of PDL and acellular cementum through periostin and fibronectin expression.; J-STAGE
• 国立国会図書館永続的識別子: info:ndljp/pid/10319028; https://dl.ndl.go.jp/pid/10319028
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-04-02T16:10:31+09:00
• 作成日（W3CDTF）: 2017-03-29
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 原資料（URI）: http://doi.org/10.2220/biomedres.38.61
• 掲載誌（URI）: https://fdc.repo.nii.ac.jp/records/70
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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