Hertwig's epithelial root sheath cells contribute to formation of periodontal ligament through epithelial-mesenchymal transition by TGF-β.

• Material Type: 博士論文
• Title: Hertwig's epithelial root sheath cells contribute to formation of periodontal ligament through epithelial-mesenchymal transition by TGF-β.
• Author/Editor: Itaya, Satoshi; Oka, Kyoko; Ogata, Kayoko; Tamura, Shougo; Kira-Tatsuoka, Michiko; Fujiwara, Naoki; Otsu, Keishi; Tsuruga, Eichi; Ozaki, Masao; Harada, Hidemitsu
• Author Heading: Itaya, Satoshi; Oka, Kyoko; Ogata, Kayoko; Tamura, Shougo; Kira-Tatsuoka, Michiko; Fujiwara, Naoki; Otsu, Keishi; Tsuruga, Eichi; Ozaki, Masao; Harada, Hidemitsu
• Publication Date: 2017-03-11
• Publication Date (W3CDTF): 2017-03-11
• Alternative Title: Hertwig's epithelial root sheath cells contribute to formation of periodontal ligament through epithelial-mesenchymal transition by TGF-β.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2017-03-11
• Date Granted (W3CDTF): 2017-03-11
• Dissertation Number: 甲第284号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第284号
• Text Language Code: eng
• Subject Heading: ヘルトヴィッヒ上皮鞘; 上皮間葉転換; TGF-β; Hertwig's epithelial root sheath; Alkaline Phosphatase; Animals; Cadherins; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cell Line; Collagen Type I; Core Binding Factor Alpha 1 Subunit; Dental Cementum; Epithelial Cells; Epithelial-Mesenchymal Transition; Extracellular Matrix; Fibronectins; Gene Expression Regulation; Mice; Odontoblasts; Osteocalcin; Periodontal Ligament; Tooth Root; Transcription Factors; Transforming Growth Factor beta1
• Target Audience: 一般
• Note (General): In tooth root development, periodontal ligament (PDL) and cementum are formed by the coordination with the fragmentation of Hertwig's epithelial root sheath (HERS) and the differentiation of dental follicle mesenchymal cells. However, the function of the dental epithelial cells after HERS fragmentation in the PDL is not fully understood. Here, we found that TGF-β regulated HERS fragmentation via epithelial-mesenchymal transition (EMT), and the fragmented epithelial cells differentiated into PDL fibroblastic cells with expressing of PDL extracellular matrix (ECM). In the histochemical analysis, TGF-β was expressed in odontoblast layer adjacent of HERS during root development. Periostin expression was detected around fragmented epithelial cells on the root surface, but not in HERS. In the experiment using an established mouse HERS cell line (HERS01a), TGF-β1 treatment decreased E-cadherin and relatively increased N-cadherin expression. TGF-β1 treatment in HERS01a induced further expression of important ECM proteins for acellular cementum and PDL development such as fibronectin and periostin. Taken together, activation of TGF-βsignaling induces HERS fragmentation through EMT and the fragmented HERS cells contribute to formation of PDL and acellular cementum through periostin and fibronectin expression.; J-STAGE
• Persistent ID (NDL): info:ndljp/pid/10319028; https://dl.ndl.go.jp/pid/10319028
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-04-02T16:10:31+09:00
• Date Created (W3CDTF): 2017-03-29
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): http://doi.org/10.2220/biomedres.38.61
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/70
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2023-08-05 再収集

2023-08-05 再収集

2023-08-05 再収集

2023-12-08 再収集

2023-12-08 再収集