Cortico-cortical evoked hemodynamic responses in human language systems using intraoperative near-infrared spectroscopy during direct cortical stimulation.

• 資料種別: 博士論文
• タイトル: Cortico-cortical evoked hemodynamic responses in human language systems using intraoperative near-infrared spectroscopy during direct cortical stimulation.
• 著者・編者: Sato, Keisuke
• 出版事項: 新潟大学
• 出版年月日等: 2017-03-23
• 出版年（W3CDTF）: 2017-03-23
• 並列タイトル等: Cortico-cortical evoked hemodynamic responses in human language systems using intraoperative near-infrared spectroscopy during direct cortical stimulation.; 術中皮質電気刺激下NIRS同時記録による, ヒト言語野(前頭葉-側頭葉)における皮質-皮質間誘発血流変化の検討
• 授与機関名: 新潟大学
• 授与年月日: 2017-03-23
• 授与年月日（W3CDTF）: 2017-03-23
• 報告番号: 甲第4253号
• 学位: 博士（医学）
• 博論授与番号: 甲第4253号
• 本文の言語コード: eng
• 件名標目: Cortico-cortical network; Direct cortical stimulation; Epilepsy surgery; Language systems; Near-infrared spectroscopy
• 一般注記: Background : Understanding of cortico-cortical activity in eloquent areas intraoperatively is crucial for neurosurgical procedures. Here, we used intraoperative near-infrared spectroscopy (iNIRS) during direct cortical stimulation as a robust tool to better understand the cortico-cortical connectivity in language systems.Methods : We applied iNIRS to 3 patients who underwent epilepsy surgery due to lesions (cavernous angioma, epidermoid cyst, and low-grade glioma) located in language areas. Using iNIRS, we measured the blood concentration changes of oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) in the lateral temporal cortex during direct cortical stimulation (50 Hz) at the inferior frontal area where Broca’s area was probabilistically located.Results : In all patients, 50 Hz stimulation elicited hemodynamic changes in the superior temporal gyrus (STG). During 0.8–4.8 s after stimulation, HbO2 increased and HbR decreased in the posterior part of the STG (Wernicke’s area). Similar responses were observed in the anterior part of the STG 1.3–8.0 s after stimulation. Finally, these changes were disappeared in the middle temporal gyrus.Conclusions : Our results suggest that cortical stimulation of Broca’s area elicits hemodynamic responses in Wernicke's area via cortico-cortical connectivity. We demonstrated cortico-cortical evoked responses in language systems using iNIRS during direct cortical stimulation. Our iNIRS data will provide useful information about cortico-cortical networks underlying human brain functions intraoperatively and will contribute to neurosurgical treatment in eloquent areas.; 学位の種類: 博士（医学）. 報告番号: 甲第4253号. 学位記番号: 新大院博（医）甲第731号. 学位授与年月日: 平成29年3月23日; Neuroscience Letters 630.136-140,2016; 新大院博（医）甲第731号; 元資料の権利情報 : © 2016 Elsevier Inc. All rights reserved
• DOI: info:doi/10.1016/j.neulet.2016.07.037; https://doi.org/info:doi/10.1016/j.neulet.2016.07.037
• 国立国会図書館永続的識別子: info:ndljp/pid/10371262; https://dl.ndl.go.jp/pid/10371262
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-07-03T04:10:06+09:00
• 作成日（W3CDTF）: 2019-08-05
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10191/47584
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp