Cortico-cortical evoked hemodynamic responses in human language systems using intraoperative near-infrared spectroscopy during direct cortical stimulation.

• Material Type: 博士論文
• Title: Cortico-cortical evoked hemodynamic responses in human language systems using intraoperative near-infrared spectroscopy during direct cortical stimulation.
• Author/Editor: Sato, Keisuke
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2017-03-23
• Publication Date (W3CDTF): 2017-03-23
• Alternative Title: Cortico-cortical evoked hemodynamic responses in human language systems using intraoperative near-infrared spectroscopy during direct cortical stimulation.; 術中皮質電気刺激下NIRS同時記録による, ヒト言語野(前頭葉-側頭葉)における皮質-皮質間誘発血流変化の検討
• Degree grantor/type: 新潟大学
• Date Granted: 2017-03-23
• Date Granted (W3CDTF): 2017-03-23
• Dissertation Number: 甲第4253号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4253号
• Text Language Code: eng
• Subject Heading: Cortico-cortical network; Direct cortical stimulation; Epilepsy surgery; Language systems; Near-infrared spectroscopy
• Note (General): Background : Understanding of cortico-cortical activity in eloquent areas intraoperatively is crucial for neurosurgical procedures. Here, we used intraoperative near-infrared spectroscopy (iNIRS) during direct cortical stimulation as a robust tool to better understand the cortico-cortical connectivity in language systems.Methods : We applied iNIRS to 3 patients who underwent epilepsy surgery due to lesions (cavernous angioma, epidermoid cyst, and low-grade glioma) located in language areas. Using iNIRS, we measured the blood concentration changes of oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) in the lateral temporal cortex during direct cortical stimulation (50 Hz) at the inferior frontal area where Broca’s area was probabilistically located.Results : In all patients, 50 Hz stimulation elicited hemodynamic changes in the superior temporal gyrus (STG). During 0.8–4.8 s after stimulation, HbO2 increased and HbR decreased in the posterior part of the STG (Wernicke’s area). Similar responses were observed in the anterior part of the STG 1.3–8.0 s after stimulation. Finally, these changes were disappeared in the middle temporal gyrus.Conclusions : Our results suggest that cortical stimulation of Broca’s area elicits hemodynamic responses in Wernicke's area via cortico-cortical connectivity. We demonstrated cortico-cortical evoked responses in language systems using iNIRS during direct cortical stimulation. Our iNIRS data will provide useful information about cortico-cortical networks underlying human brain functions intraoperatively and will contribute to neurosurgical treatment in eloquent areas.; 学位の種類: 博士（医学）. 報告番号: 甲第4253号. 学位記番号: 新大院博（医）甲第731号. 学位授与年月日: 平成29年3月23日; Neuroscience Letters 630.136-140,2016; 新大院博（医）甲第731号; 元資料の権利情報 : © 2016 Elsevier Inc. All rights reserved
• DOI: info:doi/10.1016/j.neulet.2016.07.037; https://doi.org/info:doi/10.1016/j.neulet.2016.07.037
• Persistent ID (NDL): info:ndljp/pid/10371262; https://dl.ndl.go.jp/pid/10371262
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-07-03T04:10:06+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/47584
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp