Utility of right ventricular Tei-index for assessing disease severity and determining response to treatment in patients with pulmonary arterial hypertension

• 資料種別: 博士論文
• タイトル: Utility of right ventricular Tei-index for assessing disease severity and determining response to treatment in patients with pulmonary arterial hypertension
• 著者・編者: Ogihara, Yoshito
• 著者標目: Ogihara, Yoshito
• 出版事項: 三重大学
• 出版年月日等: 2016-03-25
• 出版年（W3CDTF）: 2016-03-25
• 並列タイトル等: 肺動脈性肺高血圧患者の重症度評価および治療効果判定における右室Tei indexの有用性の検討
• 授与機関名: 三重大学
• 授与年月日: 2016-03-25
• 授与年月日（W3CDTF）: 2016-03-25
• 報告番号: 甲医学第1773号
• 学位: 博士(医学)
• 博論授与番号: 甲医学第1773号
• 本文の言語コード: eng
• 著者別名: オギハラ, ヨシト; 荻原, 義人
• 件名標目: Right ventricular Tei-index; Pulmonary arterial hypertension; Clinical marker
• 対象利用者: 一般
• 一般注記: application/pdf; Background: We sought to evaluate the potential utility of echocardiography-derived morphological and functional right ventricular (RV) variables for assessing disease severity of pulmonary arterial hypertension (PAH) and determining the changes in the patient’s hemodynamics in the clinical course. Methods and results: This study consisted of 24 normal controls (the control group) and 24 patients with PAH at rest or with exercise (the PAH group) who underwent echocardiography, right heart catheterization, plasma brain natriuretic peptide (BNP) measurement, and six-minute walk distance (6MWD) test. The PAH group had poorer RV echocardiographic variables than the control group. RV Tei-index was more strongly correlated with 6MWD, BNP, cardiac index, mean pulmonary arterial pressure, and pulmonary vascular resistance (PVR) than other RV echocardiography-derived variables including RV end-diastolic areas, RV fractional area change, and tricuspid annular plane systolic excursion. In 16 of the 24 patients who successfully underwent repeated examination during follow up (13.3±4.9 months; range, 5-24 months), PVR decreased from 486±380 dyne s cm−5 to 346±252 dyne s cm−5, and RV Teiindex decreased from 0.55±0.30 to 0.42±0.17, and the changes in RV Tei-index were correlated with the concomitant changes in PVR during the clinical course of PAH (r = 0.706, p = 0.002). Tricuspid annular plane systolic excursion and RV fractional area change did not change during the follow up. Conclusions: Quantitative echocardiography revealed that the measurement of RV Tei-index is of great clinical utility for predicting disease severity of PAH and determining the changes in the patient’s hemodynamics in the clinical course.; 本文 / Department of Cardiology and Nephrology, Mie University Graduate School of Medicine; 5p; https://doi.org/10.1016/j.jjcc.2013.07.002
• DOI: info:doi/10.1016/j.jjcc.2013.07.002; https://doi.org/info:doi/10.1016/j.jjcc.2013.07.002
• 国立国会図書館永続的識別子: info:ndljp/pid/10402948; https://dl.ndl.go.jp/pid/10402948
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-08-02T04:31:34+09:00
• 作成日（W3CDTF）: 2017-07-04
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 関連情報（URI）: https://doi.org/10.1016/j.jjcc.2013.07.002
• 掲載誌（URI）: http://hdl.handle.net/10076/00016978; https://mie-u.repo.nii.ac.jp/records/11322
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2017-11-03 再収集

2023-12-15 再収集