Alternative Title肺動脈性肺高血圧患者の重症度評価および治療効果判定における右室Tei indexの有用性の検討
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Background: We sought to evaluate the potential utility of echocardiography-derived morphological and functional right ventricular (RV) variables for assessing disease severity of pulmonary arterial hypertension (PAH) and determining the changes in the patient’s hemodynamics in the clinical course. Methods and results: This study consisted of 24 normal controls (the control group) and 24 patients with PAH at rest or with exercise (the PAH group) who underwent echocardiography, right heart catheterization, plasma brain natriuretic peptide (BNP) measurement, and six-minute walk distance (6MWD) test. The PAH group had poorer RV echocardiographic variables than the control group. RV Tei-index was more strongly correlated with 6MWD, BNP, cardiac index, mean pulmonary arterial pressure, and pulmonary vascular resistance (PVR) than other RV echocardiography-derived variables including RV end-diastolic areas, RV fractional area change, and tricuspid annular plane systolic excursion. In 16 of the 24 patients who successfully underwent repeated examination during follow up (13.3±4.9 months; range, 5-24 months), PVR decreased from 486±380 dyne s cm−5 to 346±252 dyne s cm−5, and RV Teiindex decreased from 0.55±0.30 to 0.42±0.17, and the changes in RV Tei-index were correlated with the concomitant changes in PVR during the clinical course of PAH (r = 0.706, p = 0.002). Tricuspid annular plane systolic excursion and RV fractional area change did not change during the follow up. Conclusions: Quantitative echocardiography revealed that the measurement of RV Tei-index is of great clinical utility for predicting disease severity of PAH and determining the changes in the patient’s hemodynamics in the clinical course.
本文 / Department of Cardiology and Nephrology, Mie University Graduate School of Medicine
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https://doi.org/10.1016/j.jjcc.2013.07.002
DOIinfo:doi/10.1016/j.jjcc.2013.07.002
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2017-08-02T04:31:34+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション