CD40 Expression in Human Esophageal Squamous Cell Carcinoma Is Associated with Tumor Progression and Lymph Node Metastasis

• 資料種別: 博士論文
• タイトル: CD40 Expression in Human Esophageal Squamous Cell Carcinoma Is Associated with Tumor Progression and Lymph Node Metastasis
• 著者・編者: 松村, 祥幸
• 著者標目: 松村, 祥幸
• 出版事項: Hokkaido University
• 出版年月日等: 2017-03-23
• 出版年（W3CDTF）: 2017-03-23
• 並列タイトル等: 食道扁平上皮癌におけるCD40の発現は腫瘍の進行とリンパ節転移に関係する
• 寄与者: 秋田, 弘俊; 本間, 明宏; 平野, 聡
• 授与機関名: 北海道大学
• 授与年月日: 2017-03-23
• 授与年月日（W3CDTF）: 2017-03-23
• 報告番号: 甲第12531号
• 学位: 博士(医学)
• 博論授与番号: 甲第12531号
• 本文の言語コード: eng
• 件名標目: CD40; CD154; CD40 ligand; CD40L; esophageal squamous cell carcinoma; IL6
• NDC: 490
• 対象利用者: 一般
• 一般注記: Citation: YOSHIYUKI MATSUMURA, KEI HIRAOKA, KEIDAI ISHIKAWA, YASUHITO SHOJI, TAKEHIRO NOJI, KOJI HONTANI, TOMOO ITOH, TORU NAKAMURA, TAKAHIRO TSUCHIKAWA, TOSHIAKI SHICHINOHE and SATOSHI HIRANO. CD40 Expression in Human Esophageal Squamous Cell Carcinoma Is Associated with Tumor Progression and Lymph Node Metastasis. ANTICANCER RESEARCH 36(9): 4467-4475 (2016). doi:10.21873/anticanres.10991; 配架番号：2272; Background: The co-stimulatory molecule cluster of differentiation 40 (CD40) is widely expressed in various types of malignant tumors, but its role remains unclear. The purpose of this study was to investigate the relationship between CD40 expression and clinicopathological variables in patients with esophageal squamous cell carcinoma (ESCC), as well as the function of CD40 expressed on ESCC tumor cells in vitro. Materials and Methods: Tumor specimens of patients who underwent surgical resection for ESCC were immunohistochemically analyzed for CD40 expression. Results: Of the 122 specimens, 45 (37%) were positive for CD40. Significant positive correlation was found between CD40 expression and p-stage (p=0.0011), histopathological grade (p=0.0143), pT-classification (p=0.0011), and pN-classification (p=0.0007). Survival of patients with stage III and IV disease with positive CD40 expression was significantly shorter than that of those with negative expression (log-rank test, p=0.0422). In in vitro analysis, while the addition of recombinant human CD154 did not inhibit growth, it did induce a significant increase in interleukin 6 production in ESCC cell lines. Conclusion: These results suggest that functional expression of CD40 on tumor cells might play an important role in tumor progression and lymph node metastasis in ESCC.; (主査) 教授 秋田 弘俊, 准教授 本間 明宏, 教授 平野 聡; 医学研究科（癌医学専攻）
• DOI: 10.14943/doctoral.k12531; https://doi.org/10.14943/doctoral.k12531
• 国立国会図書館永続的識別子: info:ndljp/pid/10403206; https://dl.ndl.go.jp/pid/10403206
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-08-02T04:31:34+09:00
• 作成日（W3CDTF）: 2017-03
• 記録形式（IMT）: PDF
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://dx.doi.org/10.14943/doctoral.k12531; http://hdl.handle.net/2115/66618
• 参照（URI）: http://hdl.handle.net/2115/65877
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• 要約等: Background: The co-stimulatory molecule cluster of differentiation 40 (CD40) is widely expressed in various types of malignant tumors, but its role re...