CD40 Expression in Human Esophageal Squamous Cell Carcinoma Is Associated with Tumor Progression and Lymph Node Metastasis

• Material Type: 博士論文
• Title: CD40 Expression in Human Esophageal Squamous Cell Carcinoma Is Associated with Tumor Progression and Lymph Node Metastasis
• Author/Editor: 松村, 祥幸
• Author Heading: 松村, 祥幸
• Publication, Distribution, etc.: Hokkaido University
• Publication Date: 2017-03-23
• Publication Date (W3CDTF): 2017-03-23
• Alternative Title: 食道扁平上皮癌におけるCD40の発現は腫瘍の進行とリンパ節転移に関係する
• Contributor: 秋田, 弘俊; 本間, 明宏; 平野, 聡
• Degree grantor/type: 北海道大学
• Date Granted: 2017-03-23
• Date Granted (W3CDTF): 2017-03-23
• Dissertation Number: 甲第12531号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第12531号
• Text Language Code: eng
• Subject Heading: CD40; CD154; CD40 ligand; CD40L; esophageal squamous cell carcinoma; IL6
• NDC: 490
• Target Audience: 一般
• Note (General): Citation: YOSHIYUKI MATSUMURA, KEI HIRAOKA, KEIDAI ISHIKAWA, YASUHITO SHOJI, TAKEHIRO NOJI, KOJI HONTANI, TOMOO ITOH, TORU NAKAMURA, TAKAHIRO TSUCHIKAWA, TOSHIAKI SHICHINOHE and SATOSHI HIRANO. CD40 Expression in Human Esophageal Squamous Cell Carcinoma Is Associated with Tumor Progression and Lymph Node Metastasis. ANTICANCER RESEARCH 36(9): 4467-4475 (2016). doi:10.21873/anticanres.10991; 配架番号：2272; Background: The co-stimulatory molecule cluster of differentiation 40 (CD40) is widely expressed in various types of malignant tumors, but its role remains unclear. The purpose of this study was to investigate the relationship between CD40 expression and clinicopathological variables in patients with esophageal squamous cell carcinoma (ESCC), as well as the function of CD40 expressed on ESCC tumor cells in vitro. Materials and Methods: Tumor specimens of patients who underwent surgical resection for ESCC were immunohistochemically analyzed for CD40 expression. Results: Of the 122 specimens, 45 (37%) were positive for CD40. Significant positive correlation was found between CD40 expression and p-stage (p=0.0011), histopathological grade (p=0.0143), pT-classification (p=0.0011), and pN-classification (p=0.0007). Survival of patients with stage III and IV disease with positive CD40 expression was significantly shorter than that of those with negative expression (log-rank test, p=0.0422). In in vitro analysis, while the addition of recombinant human CD154 did not inhibit growth, it did induce a significant increase in interleukin 6 production in ESCC cell lines. Conclusion: These results suggest that functional expression of CD40 on tumor cells might play an important role in tumor progression and lymph node metastasis in ESCC.; (主査) 教授 秋田 弘俊, 准教授 本間 明宏, 教授 平野 聡; 医学研究科（癌医学専攻）
• DOI: 10.14943/doctoral.k12531; https://doi.org/10.14943/doctoral.k12531
• Persistent ID (NDL): info:ndljp/pid/10403206; https://dl.ndl.go.jp/pid/10403206
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-08-02T04:31:34+09:00
• Date Created (W3CDTF): 2017-03
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.14943/doctoral.k12531; http://hdl.handle.net/2115/66618
• Is Referenced By (URI): http://hdl.handle.net/2115/65877
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• Summary, etc.: Background: The co-stimulatory molecule cluster of differentiation 40 (CD40) is widely expressed in various types of malignant tumors, but its role re...