Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis

• 資料種別: 博士論文
• タイトル: Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis
• 著者・編者: Tsuchida, Junko
• 出版事項: 新潟大学
• 出版年月日等: 2017-09-20
• 出版年（W3CDTF）: 2017-09-20
• 並列タイトル等: Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis; 乳癌におけるスフィンゴシン1リン酸濃度と，リン酸化スフィンゴシンキナーゼ１の発現およびリンパ節転移と関連
• 授与機関名: 新潟大学
• 授与年月日: 2017-09-20
• 授与年月日（W3CDTF）: 2017-09-20
• 報告番号: 甲第4366号
• 学位: 博士（医学）
• 博論授与番号: 甲第4366号
• 本文の言語コード: eng
• 件名標目: Sphingosine-1-phosphate; Phospho-sphingosine kinase 1; Breast cancer; Lymphatic metastasis; HER2; Inflammation
• 一般注記: Background: Sphingosine-1-phosphate (S1P), a pleiotropic bioactive lipid mediator, has been implicated as a key regulatory molecule in cancer through its ability to promote cell proliferation, migration, angiogenesis, and lymphangiogenesis. Previous studies suggested that S1P produced by sphingosine kinase 1 (SphK1) in breast cancer plays important roles in progression of disease and metastasis. However, the associations between S1P and clinical parameters in human breast cancer have not been well investigated to date. Materials and methods: We determined levels of S1P and other sphingolipids in breast cancer tissue by electrospray ionization-tandem mass spectrometry. Associations between S1P levels and clinicopathologic features of the tumors were analyzed. Expression of phospho-SphK1 (pSphK1) in breast cancer tissues was determined by immunohistochemical scoring. Results: Levels of S1P in breast cancer tissues were significantly higher in patients with high white blood cell count in the blood than those patients without. S1P levels were lower in patients with human epidermal growth factor receptor 2 overexpression and/or amplification than those patients without. Furthermore, cancer tissues with high pSphK1 expression showed significantly higher levels of S1P than cancer tissues without. Finally, patients with lymph node metastasis showed significantly higher levels of S1P in tumor tissues than the patients with negative nodes. Conclusions: To our knowledge, this is the first study to demonstrate that high expression of pSphK1 is associated with higher levels of S1P, which in turn is associated with lymphatic metastasis in breast cancer.; 学位の種類: 博士（医学）. 報告番号: 甲第4366号. 学位記番号: 新大院博（医）甲第779号. 学位授与年月日: 平成29年9月20日; Journal of Surgical Research. 2016, 205(1), 85-94.; 新大院博（医）甲第779号; 元資料の権利情報 : (C) 2016 Elsevier Inc. All rights reserved.
• DOI: info:doi/10.1016/j.jss.2016.06.022; https://doi.org/info:doi/10.1016/j.jss.2016.06.022
• 国立国会図書館永続的識別子: info:ndljp/pid/10993762; https://dl.ndl.go.jp/pid/10993762
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-12-04T02:02:48+09:00
• 作成日（W3CDTF）: 2019-08-05
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10191/48156
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp