Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis

• Material Type: 博士論文
• Title: Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis
• Author/Editor: Tsuchida, Junko
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2017-09-20
• Publication Date (W3CDTF): 2017-09-20
• Alternative Title: Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis; 乳癌におけるスフィンゴシン1リン酸濃度と，リン酸化スフィンゴシンキナーゼ１の発現およびリンパ節転移と関連
• Degree grantor/type: 新潟大学
• Date Granted: 2017-09-20
• Date Granted (W3CDTF): 2017-09-20
• Dissertation Number: 甲第4366号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4366号
• Text Language Code: eng
• Subject Heading: Sphingosine-1-phosphate; Phospho-sphingosine kinase 1; Breast cancer; Lymphatic metastasis; HER2; Inflammation
• Note (General): Background: Sphingosine-1-phosphate (S1P), a pleiotropic bioactive lipid mediator, has been implicated as a key regulatory molecule in cancer through its ability to promote cell proliferation, migration, angiogenesis, and lymphangiogenesis. Previous studies suggested that S1P produced by sphingosine kinase 1 (SphK1) in breast cancer plays important roles in progression of disease and metastasis. However, the associations between S1P and clinical parameters in human breast cancer have not been well investigated to date. Materials and methods: We determined levels of S1P and other sphingolipids in breast cancer tissue by electrospray ionization-tandem mass spectrometry. Associations between S1P levels and clinicopathologic features of the tumors were analyzed. Expression of phospho-SphK1 (pSphK1) in breast cancer tissues was determined by immunohistochemical scoring. Results: Levels of S1P in breast cancer tissues were significantly higher in patients with high white blood cell count in the blood than those patients without. S1P levels were lower in patients with human epidermal growth factor receptor 2 overexpression and/or amplification than those patients without. Furthermore, cancer tissues with high pSphK1 expression showed significantly higher levels of S1P than cancer tissues without. Finally, patients with lymph node metastasis showed significantly higher levels of S1P in tumor tissues than the patients with negative nodes. Conclusions: To our knowledge, this is the first study to demonstrate that high expression of pSphK1 is associated with higher levels of S1P, which in turn is associated with lymphatic metastasis in breast cancer.; 学位の種類: 博士（医学）. 報告番号: 甲第4366号. 学位記番号: 新大院博（医）甲第779号. 学位授与年月日: 平成29年9月20日; Journal of Surgical Research. 2016, 205(1), 85-94.; 新大院博（医）甲第779号; 元資料の権利情報 : (C) 2016 Elsevier Inc. All rights reserved.
• DOI: info:doi/10.1016/j.jss.2016.06.022; https://doi.org/info:doi/10.1016/j.jss.2016.06.022
• Persistent ID (NDL): info:ndljp/pid/10993762; https://dl.ndl.go.jp/pid/10993762
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2017-12-04T02:02:48+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/48156
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp