Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses

• 資料種別: 記事
• タイトル: Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses
• 著者・編者: Muhareva Raekiansyah; Mihoko Mori; Kenichi Nonaka
• 出版事項: 日本 : Springer Nature
• 出版年月日等: 2017-10-26
• 出版年（W3CDTF）: 2017-10-26
• タイトル（掲載誌）: Tropical medicine and health
• 巻号年月日等（掲載誌）: 45(32)
• 掲載巻: 45(32)
• ISSN（掲載誌）: 1349-4147
• ISSN-L（掲載誌）: 1348-8945
• 本文の言語コード: eng
• DOI: 10.1186/s41182-017-0072-7; https://doi.org/10.1186/s41182-017-0072-7
• 国立国会図書館永続的識別子: info:ndljp/pid/11010649; https://dl.ndl.go.jp/pid/11010649
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• 収集根拠: オンライン資料収集制度
• 受理日（W3CDTF）: 2018-01-06T04:34:48+09:00
• 保存日（W3CDTF）: 2018-01-05
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://tropmedhealth.biomedcentral.com/articles
• 掲載誌（国立国会図書館永続的識別子）: info:ndljp/pid/10369860; https://dl.ndl.go.jp/pid/10369860
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• 要約等: Microbial natural products possess a wide range of biological and biochemical potential. Among them, fungal secondary metabolites are one of the most important sources for discovering new drugs or lead compounds. In the present study, we explored substances produced by the strain Penicillium sp. FKI-7127 for its antiviral activity. We identified brefeldin A as a novel antiviral agent against dengue viruses. The inhibitory effect of brefeldin A was confirmed by virus titer and immunofluorescence assay. Brefeldin A inhibited dengue viruses regardless of serotypes and other related viruses including Zika virus and Japanese encephalitis virus. Time-of-addition study showed that brefeldin A exerts its antiviral effect at an early stage of the dengue virus (DENV) life cycle. These studies demonstrate that (i) brefeldin A could be used as a lead compound for drug development of anti-DENV and other related viruses and (ii) fungal metabolites are a potential and valuable source for dengue virus drug discovery.; Tropical Medicine and Health, 45, 32; 2017
• DOI: 10.1186/s41182-017-0072-7; https://doi.org/10.1186/s41182-017-0072-7
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: c The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
• 関連情報（URI）: http://hdl.handle.net/10069/37906; https://nagasaki-u.repo.nii.ac.jp/records/2684; http://id.ndl.go.jp/digimeta/11010649; https://dl.ndl.go.jp/pid/11010649; http://link.springer.com/content/pdf/10.1186/s41182-017-0072-7.pdf; https://search.jamas.or.jp/link/ui/2019252207
• 参照: Mx Is Not Responsible for the Antiviral Activity of Interferon-α against Japanese Encephalitis Virus; https://cir.nii.ac.jp/crid/1360011144656813568; Characterization of the 2013 dengue epidemic in Myanmar with dengue virus 1 as the dominant serotype; https://cir.nii.ac.jp/crid/1360011145235223552; Effect of Brefeldin A on Rotavirus Assembly and Oligosaccharide Processing; https://cir.nii.ac.jp/crid/1360292619178094080; Natural products: A continuing source of novel drug leads; https://cir.nii.ac.jp/crid/1360574092885204608; FLAVIVIRUS GENOME ORGANIZATION, EXPRESSION, AND REPLICATION; https://cir.nii.ac.jp/crid/1360574093580231168; Dengue; https://cir.nii.ac.jp/crid/1360574094644647296; Brefeldin A arrests the maturation and egress of herpes simplex virus particles during infection; https://cir.nii.ac.jp/crid/1360574095972475392; The global distribution and burden of dengue; https://cir.nii.ac.jp/crid/1361137044225776768; Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER; https://cir.nii.ac.jp/crid/1361137046303312256; Brefeldin A Inhibits the Processing and Secretion of Envelope Glycoproteins of Human Immunodeficiency Virus Type 1; https://cir.nii.ac.jp/crid/1361418519692819840; Potential of small-molecule fungal metabolites in antiviral chemotherapy; https://cir.nii.ac.jp/crid/1361699996109892736; Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana; https://cir.nii.ac.jp/crid/1361981468969085824; The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase; https://cir.nii.ac.jp/crid/1361981470067571072; Oblongolides from the Endophytic Fungus <i>Phomopsis</i> sp. BCC 9789; https://cir.nii.ac.jp/crid/1362262945033202048; Biological effects of the antibiotic brefeldin A (Decumbin, cyanein, ascotoxin, synergisidin): A retrospective; https://cir.nii.ac.jp/crid/1362544419609943936; Brefeldin A Inhibits Cell-Free, De Novo Synthesis of Poliovirus; https://cir.nii.ac.jp/crid/1363107368320881536; Production of valuable compounds by molds and yeasts; https://cir.nii.ac.jp/crid/1363107368694228224; Endophytic fungi—The treasure chest of antibacterial substances; https://cir.nii.ac.jp/crid/1363670318553030528; Inhibition of poliovirus RNA synthesis by brefeldin A; https://cir.nii.ac.jp/crid/1363951795512459648; Decumbin, a New Compound from a Species of Penicillium; https://cir.nii.ac.jp/crid/1364233268696422272; Dengue Virus neither Directly Mediates Hyperpermeability nor Enhances Tumor Necrosis Factor-^|^alpha;-Induced Permeability In Vitro; https://cir.nii.ac.jp/crid/1390282681217919488
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: 学術機関リポジトリデータベース; https://irdb.nii.ac.jp; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org; CiNii Articles; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja
• 書誌ID（NDLBibID）: 11010649; http://id.ndl.go.jp/bib/11010649
• NII論文ID: 120006987373