Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses
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- Material Type
- 記事
- Author/Editor
- Muhareva RaekiansyahMihoko MoriKenichi Nonaka
- Publication, Distribution, etc.
- Publication Date
- 2017-10-26
- Publication Date (W3CDTF)
- 2017-10-26
- Periodical title
- Tropical medicine and health
- No. or year of volume/issue
- 45(32)
- Volume
- 45(32)
- ISSN (Periodical Title)
- 1349-4147
- ISSN-L (Periodical Title)
- 1348-8945
- Text Language Code
- eng
- DOI
- 10.1186/s41182-017-0072-7
- Persistent ID (NDL)
- info:ndljp/pid/11010649
- Collection
- Collection (Materials For Handicapped People:1)
- Collection (particular)
- 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他
- Acquisition Basis
- オンライン資料収集制度
- Date Accepted (W3CDTF)
- 2018-01-06T04:34:48+09:00
- Date Captured (W3CDTF)
- 2018-01-05
- Format (IMT)
- application/pdf
- Access Restrictions
- 国立国会図書館内限定公開
- Service for the Digitized Contents Transmission Service
- 図書館・個人送信対象外
- Availability of remote photoduplication service
- 可
- Periodical Title (URI)
- Periodical Title (Persistent ID (NDL))
- info:ndljp/pid/10369860
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館デジタルコレクション
- Summary, etc.
- Microbial natural products possess a wide range of biological and biochemical potential. Among them, fungal secondary metabolites are one of the most important sources for discovering new drugs or lead compounds. In the present study, we explored substances produced by the strain Penicillium sp. FKI-7127 for its antiviral activity. We identified brefeldin A as a novel antiviral agent against dengue viruses. The inhibitory effect of brefeldin A was confirmed by virus titer and immunofluorescence assay. Brefeldin A inhibited dengue viruses regardless of serotypes and other related viruses including Zika virus and Japanese encephalitis virus. Time-of-addition study showed that brefeldin A exerts its antiviral effect at an early stage of the dengue virus (DENV) life cycle. These studies demonstrate that (i) brefeldin A could be used as a lead compound for drug development of anti-DENV and other related viruses and (ii) fungal metabolites are a potential and valuable source for dengue virus drug discovery.Tropical Medicine and Health, 45, 32; 2017
- DOI
- 10.1186/s41182-017-0072-7
- Access Restrictions
- インターネット公開
- Rights (production)
- c The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Related Material (URI)
- References
- Mx Is Not Responsible for the Antiviral Activity of Interferon-α against Japanese Encephalitis VirusCharacterization of the 2013 dengue epidemic in Myanmar with dengue virus 1 as the dominant serotypeEffect of Brefeldin A on Rotavirus Assembly and Oligosaccharide ProcessingNatural products: A continuing source of novel drug leadsFLAVIVIRUS GENOME ORGANIZATION, EXPRESSION, AND REPLICATIONDengueBrefeldin A arrests the maturation and egress of herpes simplex virus particles during infectionThe global distribution and burden of dengueRapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ERBrefeldin A Inhibits the Processing and Secretion of Envelope Glycoproteins of Human Immunodeficiency Virus Type 1Potential of small-molecule fungal metabolites in antiviral chemotherapyTaxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachianaThe Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal PeptidaseOblongolides from the Endophytic Fungus <i>Phomopsis</i> sp. BCC 9789Biological effects of the antibiotic brefeldin A (Decumbin, cyanein, ascotoxin, synergisidin): A retrospectiveBrefeldin A Inhibits Cell-Free, De Novo Synthesis of PoliovirusProduction of valuable compounds by molds and yeastsEndophytic fungi—The treasure chest of antibacterial substancesInhibition of poliovirus RNA synthesis by brefeldin ADecumbin, a New Compound from a Species of PenicilliumDengue Virus neither Directly Mediates Hyperpermeability nor Enhances Tumor Necrosis Factor-^|^alpha;-Induced Permeability In Vitro
- Data Provider (Database)
- 国立情報学研究所 : CiNii Research
- Original Data Provider (Database)
- 学術機関リポジトリデータベース雑誌記事索引データベースCrossrefCiNii Articles科学研究費助成事業データベース
- Bibliographic ID (NDL)
- 11010649
- NAID
- 120006987373